Alterations of Regional Cerebral Blood Flow in Tinnitus Patients as Assessed Using Single-Photon Emission Computed Tomography

PloS One
Takashi UeyamaYoshiki Kaneoke

Abstract

Tinnitus is the perception of phantom sound without an external auditory stimulus. Using neuroimaging techniques, such as positron emission tomography, electroencephalography, magnetoencephalography, and functional magnetic resonance imaging (fMRI), many studies have demonstrated that abnormal functions of the central nervous system are closely associated with tinnitus. In our previous research, we reported using resting-state fMRI that several brain regions, including the rectus gyrus, cingulate gyrus, thalamus, hippocampus, caudate, inferior temporal gyrus, cerebellar hemisphere, and medial superior frontal gyrus, were associated with tinnitus distress and loudness. To reconfirm these results and probe target regions for repetitive transcranial magnetic stimulation (rTMS), we investigated the regional cerebral blood flow (rCBF) between younger tinnitus patients (<60 years old) and the age-matched controls using single-photon emission computed tomography and easy Z-score imaging system. Compared with that of controls, the rCBF of tinnitus patients was significantly lower in the bilateral medial superior frontal gyri, left middle occipital gyrus and significantly higher in the bilateral cerebellar hemispheres and vermis, bilate...Continue Reading

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Citations

Jan 6, 2017·Journal of Neurophysiology·Kenichi SekiyaHidehiko Okamoto
Feb 9, 2017·Frontiers in Human Neuroscience·Yu-Chen ChenXindao Yin
Mar 21, 2018·Frontiers in Aging Neuroscience·Yuan FengXindao Yin
Jan 16, 2021·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Theresa M MarschallIris E C Sommer
May 31, 2020·Otolaryngologic Clinics of North America·Meredith E AdamsSteven W Cheung

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