Alterations of retinol-binding protein 4 species in patients with different stages of chronic kidney disease and their relation to lipid parameters

Biochemical and Biophysical Research Communications
Andrea HenzeFlorian J Schweigert

Abstract

Retinol-binding protein 4 (RBP4) is elevated in patients with chronic kidney disease (CKD) and has been discussed as marker of kidney function. In addition to an elevated concentration, the existence of truncated RBP4 species, RBP4-L (truncated at last C-terminal leucine) and RBP4-LL (truncated at both C-terminal leucines), has been reported in serum of hemodialysis patients. Since little is known about the occurrence of RBP4 species during the progression of CKD it was the aim of this study to analyse this possible association. The presence of RBP4, RBP4-L, RBP4-LL and transthyretin (TTR) was assessed in serum of 45 healthy controls and 52 patients with stage 2-5 of CKD using ELISA and RBP4 immunoprecipitation with subsequent MALDI-TOF-MS analysis. A reduction of glomerular filtration rate was accompanied by a gradual elevation of RBP4 serum levels and relative amounts of RBP4-LL. Correlation analysis revealed a strong association of the RBP4-TTR ratio with parameters of lipid metabolism and with diabetes-related factors. In conclusion, RBP4 serum concentration and the appearance of RBP4-LL seem to be influenced by kidney function. Furthermore, the RBP4-TTR ratio may provide diagnostic potential with regard to metabolic compli...Continue Reading

References

Apr 15, 1976·Clinica Chimica Acta; International Journal of Clinical Chemistry·L ScarpioniC Buzio
Jan 15, 1988·Clinica Chimica Acta; International Journal of Clinical Chemistry·A BernardR Lauwerys
Apr 1, 1971·The Journal of Clinical Investigation·R P MogielnickiW Strober
Nov 1, 1971·The Journal of Clinical Investigation·F R Smith, D S Goodman
Jan 1, 1994·Annual Review of Nutrition·Y Ingenbleek, V Young
Sep 19, 2002·Biochemical and Biophysical Research Communications·Urban A KiernanRandall W Nelson
Jan 30, 2003·Clinical Chemistry and Laboratory Medicine : CCLM·Sancia GaetaniChiara Devirgiliis
Jan 30, 2003·Clinical Chemistry and Laboratory Medicine : CCLM·Liliana B ZagoMaría E Río
Jan 30, 2003·Clinical Chemistry and Laboratory Medicine : CCLM·Noël J M Cano
Apr 29, 2003·Journal of Proteome Research·Urban A KiernanRandall W Nelson
Nov 16, 2004·Annals of Nutrition & Metabolism·Jens RailaFlorian J Schweigert
Jul 27, 2005·Proceedings of the National Academy of Sciences of the United States of America·Dobrin NedelkovRandall W Nelson
Jun 16, 2006·The New England Journal of Medicine·Timothy E GrahamBarbara B Kahn
Jul 17, 2007·Diabetes Care·Michaela ZiegelmeierMathias Fasshauer
Feb 21, 2008·American Journal of Physiology. Endocrinology and Metabolism·Nimesh ModyBarbara B Kahn
Aug 30, 2008·Lipids in Health and Disease·Simone K FreyFlorian J Schweigert

❮ Previous
Next ❯

Citations

Feb 7, 2012·The Journal of Biological Chemistry·Chao-Hung ChenShyi-Jang Shin
Oct 22, 2015·Journal of Proteome Research·Petra MuckovaHeidrun Rhode
Nov 29, 2011·Clinica Chimica Acta; International Journal of Clinical Chemistry·Keith A BurlingAnthony G W Norden
Oct 5, 2018·Rheumatology·Jessica L TurnierBruce Aronow
Nov 8, 2019·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Roman ZinderJoseph A Molnar

❮ Previous
Next ❯

Related Concepts

Related Feeds

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.