Alterations of the blood-brain barrier after transplantation of autonomic ganglia into the mammalian central nervous system

The Journal of Comparative Neurology
J M Rosenstein, M W Brightman

Abstract

Autonomic (superior cervical) ganglia, the vessels of which are freely permeable to macromolecules, from mature rat donors (allografts or autografts) were transplanted to different sites in the central nervous system (CNS). Minimal trauma was caused by grafts into the IVth ventricle while grafts to intraparenchymal locations such as cerebral cortex and spinal cord were necessarily traumatic and produced glial scarring. Postoperative periods were between 4 weeks and 30 months. A potentially significant aspect of neural transplantation is the functional vascular connections between host and graft. It is highly likely that grafting procedures alter the blood-brain barrier (BBB) in the recipient brain. In order to determine permanent BBB changes, the glycoprotein horseradish peroxidase (HRP) (M.W. 40,000) was injected intravascularly for circulation periods ranging between 50 seconds and 90 minutes. Protein exudation was monitored by using the chromogens DAB and the highly sensitive TMB. All autonomic ganglia transplants, regardless of postoperative or HRP circulation times, were permeable to the injected protein; no qualitative differences were found between allografts and autografts. The blood-borne protein traversed the autonomi...Continue Reading

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Citations

Jun 23, 1987·Brain Research·J M Rosenstein
Aug 1, 1989·Brain Research. Developmental Brain Research·I DusartM Peschanski
Jul 16, 1993·Brain Research. Developmental Brain Research·J M Krum, J M Rosenstein
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Feb 11, 2004·Experimental Neurology·Diana CasperAnn Pidel
Apr 1, 1996·Neuropathology and Applied Neurobiology·S IsenmannA Aguzzi
Jan 1, 1991·Annals of the New York Academy of Sciences·Z Nagy, K Martinez
Dec 7, 2013·Neuropathology and Applied Neurobiology·G Cisbani, F Cicchetti
Jan 1, 1987·Annals of the New York Academy of Sciences·J M Rosenstein
May 1, 1987·Neuropathology and Applied Neurobiology·F Joó
May 13, 2014·Cell Transplantation·Wise Young
Aug 1, 1989·Journal of Electron Microscopy Technique·J T HansenD M Gash
Jan 1, 1993·Reviews in the Neurosciences·C GagnonT Di Paolo
Mar 22, 1991·The Journal of Comparative Neurology·J M Rosenstein
Aug 1, 1989·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·M GuttmanD B Calne
Apr 15, 1987·The Journal of Comparative Neurology·J M Krum, J M Rosenstein

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