Alterations of the fetal capillary bed in the guinea pig placenta following long-term hypoxia

Advances in Experimental Medicine and Biology
I ScheffenK Mottaghy

Abstract

Oxygen supply is an important regulator of the fetal placental capillarization. To determine the effects of long-term hypoxia on the fetal placental vessel arrangement pregnant guinea pigs were kept under hypoxic conditions (12% O2 for 45 days). Vessel casts showed a significant difference in branching and orientation of the vessels between the controls and the hypoxic animals. The hypoxic group had a less orientated capillary bed with increased branching and coiling. By light- and transmission electron microscopical studies, there was a decreased diffusion distance, a decreased diameter of the fetal capillaries, and an increased number of capillary cross-sections. These results are consistent with the hypothesis that chronic hypoxia is responsible for increased branching and coiling of the capillaries resulting in a dense network of short and narrow capillaries in the placenta.

Citations

Sep 19, 2006·The Journal of Clinical Investigation·Manyu LiKathleen M Caron
Jul 13, 2018·Frontiers in Physiology·Emily J CammAmanda N Sferruzzi-Perri
Jan 15, 2021·The Journal of Experimental Biology·Cayleih E Robertson, Kathryn Wilsterman
Apr 30, 2002·Placenta·Keith M Godfrey

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