PMID: 9192630Jun 24, 1997Paper

Alterations of the outer membrane composition in Escherichia coli lacking the histone-like protein HU

Proceedings of the National Academy of Sciences of the United States of America
E PainbeniJ Rouviere-Yaniv

Abstract

Escherichia coli cells lacking the histone-like protein HU form filaments and have an abnormal number of anucleate cells. Furthermore, their phenotype resembles that of rfa mutants, the well-characterized deep-rough phenotype, as they show an enhanced permeability that renders them hypersensitive to chloramphenicol, novobiocin, and detergents. We show that, unlike rfa mutants, hupAB mutants do not have a truncated lipopolysaccharide but do have an abnormal abundance of OmpF porin in their outer membrane. While the complete absence of HU does not abolish the osmoregulation of OmpF protein synthesis, the steady-state level of micF RNA, the negative regulator of OmpF, decreases in bacteria lacking HU, increasing the basal level of this membrane protein. These findings demonstrate a novel link between a bacterial chromosomal protein and the outer membrane composition.

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Citations

Sep 21, 2010·Biochemistry·Katherine Y BlainSenyon Choe
Feb 13, 2013·Nature Reviews. Genetics·Xindan WangDavid Z Rudner
Mar 17, 2001·Molecular Microbiology·A BalandinaJ Rouviere-Yaniv
Oct 5, 2010·Journal of Bacteriology·Christine Alberti-SeguiMary E Davey
Nov 5, 2003·Journal of Bacteriology·Mario Alberto Flores-ValdezEdmundo Calva
Sep 5, 2002·Microbiology and Molecular Biology Reviews : MMBR·Regine Hengge-Aronis
Dec 25, 2012·Microbial Cell Factories·Franziska L LedererKatrin Pollmann
Oct 11, 2012·PloS One·Lise VanderkelenChris W Michiels
Mar 6, 2012·Biochimica Et Biophysica Acta·Mirjana Macvanin, Sankar Adhya
May 19, 2011·Helicobacter·Manuel ValenzuelaHéctor Toledo
Aug 17, 2005·FEMS Microbiology Reviews·Máire BegleyColin Hill
Jun 28, 2016·Extremophiles : Life Under Extreme Conditions·Anna C PapageorgiouConstantinos E Vorgias
Jun 14, 2000·Journal of Molecular Biology·A G PedersenD W Ussery
Sep 30, 2017·FEMS Microbiology Letters·Anteneh Hailu AbebeItzhak Fishov
Oct 10, 2002·FEBS Letters·Remus Thei Dame, Nora Goosen
Oct 17, 2001·Journal of Molecular Biology·N Delihas, S Forst

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