Alterations of the thioredoxin system during subarachnoid hemorrhage-induced cerebral vasospasm

Acta neurochirurgica
B KayaE Kalkan

Abstract

The exact underlying pathogenic mechanisms and effective preventive or therapeutic interventions for cerebral vasospasm remain obscure. The thioredoxin (Trx) system performs important functions in the central nervous system including neurotrophic and neuroprotective actions. There is no study directly investigating the effects of subarachnoid hemorrhage (SAH) induced cerebral vasospasm on the Trx system in the literature. Sixteen male New Zealand rabbits were randomly divided into two groups of eight rabbits each: a control group and a SAH group. The control group, (n = 8) was a sham surgery group in which SAH was not induced. In the SAH group, (n = 8), the SAH protocol was used to induce cerebral vasospasm. The brain and brainstem were removed and each brainstem was cut coronally into two pieces: an anterior part that contains basilar artery and a dorsal part that contains brainstem tissue. The brainstem tissue thioredoxin-1(Trx1), thioredoxin-2 (Trx2), thioredoxin reductase (TrxR), thioredoxin reductase-1 (TrxR1), thioredoxin-interacting protein (TXNIP) levels were investigated. Total oxidant status (TOS), total antioxidant status (TAS), malondialdehyde levels (MDA) and tumor necrosis factor alpha (TNF-alpha) levels were inve...Continue Reading

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Citations

May 18, 2016·Oxidative Medicine and Cellular Longevity·Xiaochun DuanGang Chen
Apr 20, 2017·International Journal of Molecular Sciences·Qing ZhaoZhaohui He
Dec 12, 2020·International Journal of Molecular Sciences·Haruka TsubakiDouglas Gordon Walker
Apr 4, 2021·International Journal of Molecular Sciences·Naila QayyumSangdun Choi

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