Alterations of the thoracic spine in Marfan's syndrome

AJR. American Journal of Roentgenology
Bernd F DaeublerSuzanne E Anderson

Abstract

The purpose of this study was to determine if the thoracic vertebral elements are altered in patients with Marfan's syndrome. Thirty patients underwent helical CT of the thorax because of suspected thoracic aortic dilatation and acute dissection. Thirteen had Marfan's syndrome and 17 did not. Two reviewers, unaware of the final diagnosis, evaluated the images by consensus for laminar thickness, foraminal width, dural sac ratios, and vertebral scalloping for T2-T12. At T9-T12, dural sac ratios at the midcorpus level (p = 0.031) and foraminal width (p = 0.0124) were significantly greater in the patients with Marfan's syndrome than in the patients without. Dural sac ratios at lower endplate levels (p = 0.0685), laminar thickness (p = 0.951), and vertebral scalloping (p = 0.24) were not significantly greater in the patients with Marfan's syndrome than in the patients without. Because the phenotypic expression of Marfan's syndrome is variable, information on the spine from thoracic studies in combination with major criteria may be helpful clinically.

References

Mar 1, 1988·American Journal of Medical Genetics·P BeightonV A McKusick
Aug 1, 1988·Journal of Neurosurgery·W E Stern
Jul 1, 1993·The Journal of Bone and Joint Surgery. American Volume·M D Smith
Apr 24, 1996·American Journal of Medical Genetics·A De PaepeR E Pyeritz
Feb 21, 1998·Nucleic Acids Research·G Collod-BéroudC Boileau
Jan 14, 2000·Journal of Medical Genetics·P N Robinson, M Godfrey
May 2, 2000·Rheumatology·N CarterP Wordsworth
Nov 7, 2000·Spine·P D SponsellerE K Fishman
Jul 31, 2001·Radiology·T OosterhofR C Hennekam
Jan 14, 2003·Matrix Biology : Journal of the International Society for Matrix Biology·Fabio QuondamatteoRainer Herken
Nov 1, 2003·The Spine Journal : Official Journal of the North American Spine Society·Leelakrishna NallamshettyPaul D Sponseller
May 27, 2004·The Journal of Biological Chemistry·Tillman VollbrandtDieter P Reinhardt

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Citations

Feb 13, 2013·Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders·Ali Al KaissiFranz Grill
Jun 21, 2014·Current Problems in Diagnostic Radiology·Tan-Lucien H MohammedJeffrey P Kanne
Jun 10, 2016·Der Nervenarzt·A ApetroaeP D Schellinger

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