Alterations of the Wnt/beta-catenin pathway and its target genes for the N- and C-terminal domains of parathyroid hormone-related protein in bone from diabetic mice

FEBS Letters
S Portal-NúñezPedro Esbrit

Abstract

Type 1 diabetes mellitus (T1D) is associated with bone loss. Given that the Wnt/beta-catenin pathway is a major regulator of bone accrual, we assessed this pathway in mice with streptozotozin-induced T1D. In diabetic mouse long bones, we found alterations favouring the suppression of this pathway by using PCR arrays and beta-catenin immunostaining. Downregulation of sclerostin, an inhibitor of this pathway, also occurred, and related to increased osteocyte apoptosis. Our data show that both N- and C-terminal parathyroid hormone-related peptide fragments might exert osteogenic effects in this setting by targeting several genes of this pathway and increasing beta-catenin in osteoblastic cells.

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Citations

Mar 19, 2013·Biochemical Pharmacology·Pedro Esbrit, María José Alcaraz
Sep 20, 2015·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Sergio Portal-NúñezPedro Esbrit
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Apr 9, 2021·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Giulia LeanzaRoberto Civitelli

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