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Alterations of Transcription of Genes Coding Anti-oxidative and Mitochondria-Related Proteins in Amyloid β Toxicity: Relevance to Alzheimer's Disease

Molecular Neurobiology

Nov 16, 2019

Magdalena CieslikJoanna Benigna Strosznajder

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Abstract

A growing body of evidence indicates that pathological forms of amyloid beta (Aβ) peptide contribute to neuronal degeneration and synaptic loss in Alzheimer's disease (AD). In this study, we investigated the impact of exogenous Aβ1-42 oligomers (AβO) and endogenously liberated Aβ peptid...read more

Mentioned in this Paper

Alzheimer's Disease
Antioxidants
Brain
Chloramphenicol O-Acetyltransferase
Cu-Zn Superoxide Dismutase
Down-Regulation
Genes
Mice, Transgenic
Mitochondria
Nerve Degeneration
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1
2
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Alterations of Transcription of Genes Coding Anti-oxidative and Mitochondria-Related Proteins in Amyloid β Toxicity: Relevance to Alzheimer's Disease

Molecular Neurobiology

Nov 16, 2019

Magdalena CieslikJoanna Benigna Strosznajder

PMID: 31734880

DOI: 10.1007/s12035-019-01819-y

Abstract

A growing body of evidence indicates that pathological forms of amyloid beta (Aβ) peptide contribute to neuronal degeneration and synaptic loss in Alzheimer's disease (AD). In this study, we investigated the impact of exogenous Aβ1-42 oligomers (AβO) and endogenously liberated Aβ peptid...read more

Mentioned in this Paper

Alzheimer's Disease
Antioxidants
Brain
Chloramphenicol O-Acetyltransferase
Cu-Zn Superoxide Dismutase
5
1
2

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