Alterations to task positive and task negative networks during executive functioning in Mild Cognitive Impairment

NeuroImage. Clinical
Rebecca J MelroseDavid L Sultzer

Abstract

Poor executive functioning increases risk of decline in Mild Cognitive Impairment (MCI). Executive functioning can be conceptualized within the framework of working memory. While some components are responsible for maintaining representations in working memory, the central executive is involved in the manipulation of information and creation of new representations. We aimed to examine the neural correlates of these components of working memory using a maintenance working memory and visuospatial reasoning task. Twenty-five patients with amnestic MCI and 19 elderly controls (EC) completed functional MRI during reasoning and maintenance working memory tasks. In MCI, maintenance working memory was associated with hypoactivation of right frontoparietal regions and hyperactivation of left prefrontal cortex, coupled with attenuation of default mode network (DMN) relative to EC. During reasoning, MCI showed hypoactivation of parietal regions, coupled with attenuation of anterior DMN and increased deactivation of posterior DMN relative to EC. Comparing the reasoning task to the maintenance working memory task yields the central executive. In MCI, the central executive showed hypoactivation of right parietal lobe and increased deactivati...Continue Reading

Citations

Sep 26, 2019·Frontiers in Aging Neuroscience·Jiao LiuUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Feb 23, 2020·Frontiers in Human Neuroscience·Qi-Hui ZhouJiang-Hong Liu
Nov 5, 2019·Behavioural Brain Research·Rebecca J MelroseAmy M Jimenez
Mar 23, 2021·Therapeutic Advances in Neurological Disorders·Michela LeocadiFederica Agosta
Apr 13, 2021·Frontiers in Aging Neuroscience·Ping-Hsuan WeiUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Apr 22, 2021·Psychological Medicine·Audreyana Jagger-RickelsMichael Esterman
May 7, 2021·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Yaoyu ZhangJia-Hong Gao

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Software Mentioned

FEAT ( fMRI Expert Analysis Tool
Brain Extraction Tool ( BET
FLIRT FMRIB Linear Image Registration Tool
FMRIB Software Library ( FSL
fslmeants
MCFLIRT
FLAME FMRIB Analysis of Mixed Effects
SPSS
FreeSurfer

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