Alterations to the pituitary-gonadal axis in the peripubertal female rat exposed in utero and through lactation to 2,3,7,8-tetrachlorodibenzo-p-dioxin

Biology of Reproduction
C L ChaffinR J Hutz

Abstract

The environmental pollutant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD; dioxin) is a potent disrupter of vertebrate endocrine systems. It was shown previously that in utero and lactational (IUL) exposure to TCDD resulted in a reduction in serum estradiol concentrations; however, the mechanism for this remains unknown. In the current study, the effects of perinatal exposure to TCDD on the pituitary-ovarian axis were examined. Pregnant rats were given a single oral dose of 1 microg TCDD/kg or vehicle as control on gestation Day 15, and female pups were killed on postnatal Day 21. Pituitaries were assayed for gonadotropin beta-subunit mRNA; additional pituitaries were cultured for 4 h and the media were assayed for FSH. Gonadotropin receptor mRNAs from vehicle- and TCDD-exposed animals were compared, with some ovaries cultured and the media assayed for estrogen secretion. LH, FSH, progesterone, and androstenedione concentrations were determined in serum. IUL exposure to TCDD resulted in a significant reduction of pituitary FSHbeta mRNA. Although estrogen output was shown to be reduced, neither serum FSH nor LH concentration was increased significantly, and FSH secretion in vitro was not altered. Similarly, serum progesterone and an...Continue Reading

Citations

Jul 9, 2004·Toxicology and Applied Pharmacology·Kimberly P MillerJodi A Flaws
Oct 3, 2003·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·V BruggemanE Decuypere
Apr 19, 2002·Toxicological Sciences : an Official Journal of the Society of Toxicology·Suzanne E FentonGeri L Youngblood
Apr 22, 2006·The Journal of Reproduction and Development·H M HoReinhold J Hutz
Sep 20, 2006·The Journal of Reproduction and Development·Mariko ShirotaKinji Shirota
Jun 28, 2007·Toxicology and Applied Pharmacology·Kimberly R BarnettJodi A Flaws
Oct 22, 2008·Fertility and Sterility·D Andrew CrainLouis J Guillette
Jun 3, 2011·Toxicology and Industrial Health·Hai-Ping YinYing Wang
Sep 6, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·S A MyllymäkiJ Paranko
Aug 29, 2018·International Journal of Molecular Sciences·Ludmila Juricek, Xavier Coumoul

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