Alterations within the rat thyroid gland during vitamin A deficiency

The American Journal of Anatomy
J M Strum

Abstract

Thyroid glands from female rats kept vitamin A deficient for one, two, and three months were examined by electron microscopy. After one month on the diet, no consistent alterations were noted. After two months, the colloid in some follicles displayed a peripheral zone of decreased density. In addition, ultimobranchial follicles within the gland had become keratinized. After two to three months on the diet, cells were seen entering the colloid. Many of these cells were identified as follicular cells since they often occurred in groups and occasionally exhibited remnants of desmosomes. Often the cells within the colloid appeared vacuolated, and by light microscopy were thought to contain lipid. However, electron microscopy revealed that these cells contained many digestive vacuoles rather than lipid droplets. Quantitative and autoradiographic studies indicated that thyroids of vitamin A deficient rats took up less radioiodide than thyroids of control rats. The keratinization of ultimorbranchial follicles in vitamin-A deficiency has been suggested as preliminary in the histogenesis of squamous cell carcinoma. However, an effect of vitamin A deficiency on thyroid follicular cells has not heretofore been reported. It's possible that...Continue Reading

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Citations

Oct 18, 2006·Thyroid : Official Journal of the American Thyroid Association·Ralf BiebingerMichael B Zimmermann
Jan 22, 2009·Journal of Nutritional Science and Vitaminology·M SiavashR Kelishadi
Jan 1, 1982·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·A J Klein-SzantoM Sega
Nov 9, 2004·The Journal of Clinical Endocrinology and Metabolism·Michael B ZimmermannT Torresani
Dec 31, 2008·International Journal of Food Sciences and Nutrition·Mahin HashemipourNavid Koleini
Feb 5, 2013·Journal of the American College of Nutrition·Mahdieh Abbasalizad FarhangiAli Akbar Saboor-Yaraghi
Mar 30, 2018·Nutrition Reviews·S Maria O'KaneAlison J Yeates
Oct 9, 2007·The American Journal of Clinical Nutrition·Michael B ZimmermannXikombiso Mbhenyane

Related Concepts

Acid Phosphatase
Autoradiography
Iodine
Iodine Radioisotopes
Thyroid Gland
Vitamin A Deficiency

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