Altered activation/detoxication enzymology following neonatal diethylstilbestrol treatment

Journal of Biochemical Toxicology
C A Lamartiniere, G A Pardo

Abstract

The effects of neonatal exposure to diethylstilbestrol (DES) on hepatic activation/detoxication enzyme levels in the adult rat were investigated. Neonatal exposure of male rats to DES (DES males) decreased the endogenous levels of UDP-glucuronyltransferase as compared to control males. Female rats exposed neonatally to DES (DES females) had higher endogenous epoxide hydrolase and glutathione transferase activity levels than control females. Adult animals treated neonatally with DES also had altered metabolic potential following exposure to 3-methylcholanthrene and phenobarbital. The DES males treated in adulthood with 3-methylcholanthrene had higher benzo(a)pyrene hydroxylase activities and lower UDP-glucuronyl-transferase activity levels than did control males treated in adulthood with 3-methylcholanthrene. The DES males exposed in adulthood to phenobarbital had reduced cytochrome P-450 and glutathione transferase activity levels as compared with respective controls. The DES females treated in adulthood with 3-methylcholanthrene had lower benzo(a)pyrene hydroxylase and epoxide hydrolase activity levels than control females receiving 3-methylcholanthrene. The DES females challenged in adulthood with phenobarbital also had decre...Continue Reading

References

Jul 1, 1976·Scientific American·B S McEwen
Jul 1, 1978·Journal of Steroid Biochemistry·C A Lamartiniere, G W Lucier
Feb 1, 1986·Journal of Steroid Biochemistry·C A LamartiniereN S Whithworth
Mar 1, 1982·Biochemical Pharmacology·C A LamartiniereN P Illsley

Citations

Jan 1, 1994·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R Anbazhagan, B A Gusterson
Jan 1, 1993·Journal of Toxicology and Environmental Health·R C ZangarD R Buhler
May 20, 2008·Toxicology and Applied Pharmacology·Ashu JohriDevendra Parmar
Jan 1, 2005·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Aramandla RameshMaurice E Knuckles
Jan 1, 1990·Annals of the New York Academy of Sciences·A Messing

Related Concepts

Xenobiotic Monooxygenases
Benzopyrene Hydroxylase
Cytochrome P-450 Oxygenase
Distilbène
Enzyme Activation
9,10-Epoxypalmitic Acid Hydrase
Yb-Glutathione-S-Transferase
Liver
Metabolic Detoxication, Drug
Methylcholanthrene

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