PMID: 7089034May 1, 1982Paper

Altered adult behavior of mice following postnatal treatment with haloperidol

Pharmacology, Biochemistry, and Behavior
G Dallemagne, B Weiss

Abstract

Haloperidol (1 and 2 mg/kg) was administered SC daily to BALB/c and Swiss/Webster mice from postnatal days 4 through 21. Non consistent statistically significant drug effects were detected on growth and reflex development. Spontaneous motor activity increased significantly in both sexes of the Swiss/Webster outbred strain, and in the Balb/c males. Performance of a fixed ratio schedule of reinforcement of both male and female haloperidol-exposed mice was not statistically different from control performance. Interpretation of such data must take into account the sensitivity of the testing devices, the effects of repeated testing of a single animal, and the suitability of traditional statistical methods in developmental pharmacology and toxicology.

References

Aug 16, 1977·Psychopharmacology·B WeissG Lusink
Jan 1, 1978·Journal of Toxicology and Environmental Health·H C Yen-KooT Balazs
Jan 1, 1970·Psychopharmacologia·C Kornetsky
Jun 1, 1968·The Journal of Genetic Psychology·E F Gauron, V N Rowley
Mar 1, 1981·Journal of Toxicology and Environmental Health·R P JenshW H Vogel
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Aug 1, 1962·Journal of Comparative and Physiological Psychology·G W MEIER, F W HUFF

Related Concepts

Behavior, Animal
Haldol
Mice, Inbred BALB C

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