PMID: 2495872Jan 1, 1989Paper

Altered amino acid levels in brainstem regions of spontaneously hypertensive rats

Clinical and Experimental Hypertension. Part A, Theory and Practice
T KuboY Misu

Abstract

The contents of glutamate, gamma-aminobutyric acid (GABA), glycine, beta-alanine and taurine in brainstem regions responsible for blood pressure regulation, the rostral ventrolateral medulla (RVL), the nucleus tractus solitarii (NTS) and the caudal ventrolateral medulla (CVL) regions, were determined in spontaneously hypertensive rats (SHR) as compared with Wistar Kyoto rats. In SHR, the content of glutamate was increased in the RVL, NTS and CVL regions whereas GABA and beta-alanine contents were decreased in the RVL and all the regions studied, respectively. There was no difference between WKY and SHR in glycine and taurine contents in all the regions studied. These results provide evidence suggesting alterations of brainstem amino acid metabolism in SHR.

References

Nov 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·F A Henn, A Hamberger
Jan 1, 1984·Journal of Neurochemistry·F Fonnum
Jun 1, 1984·Journal of Neurochemistry·K KuriyamaS Ohkuma
Sep 10, 1982·European Journal of Pharmacology·D RotirotiA P Caputi

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Citations

Feb 19, 2004·Brain Research. Molecular Brain Research·Sikha SahaTrevor F C Batten
Oct 17, 2012·Amino Acids·Sanya Roysommuti, J Michael Wyss
May 1, 1993·Clinical and Experimental Hypertension : CHE·T KuboS Ozaki
Jan 1, 1990·Clinical and Experimental Hypertension. Part A, Theory and Practice·T KuboY Misu
Jan 1, 1990·Clinical and Experimental Hypertension. Part A, Theory and Practice·T Kubo, M Kihara

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