Altered Amygdala Resting-State Functional Connectivity and Hemispheric Asymmetry in Patients With Social Anxiety Disorder

Frontiers in Psychiatry
Ye-Ha JungSoo-Hee Choi

Abstract

Background: The amygdala plays a key role in emotional hyperreactivity in response to social threat in patients with social anxiety disorder (SAD). We investigated resting-state functional connectivity (rs-FCN) of the left and right amygdala with various brain regions and functional lateralization in patients with SAD. Methods: A total of 36 patients with SAD and 42 matched healthy controls underwent functional magnetic resonance imaging (fMRI) at rest. Using the left and right amygdala as seed regions, we compared the strength of the rs-FCN in the patient and control groups. Furthermore, we investigated group differences in the hemispheric asymmetry of the functional connectivity maps of the left and right amygdala. Results: Compared with healthy controls, the rs-FCN between the left amygdala and the dorsolateral prefrontal cortex was reduced in patients with SAD, whereas left amygdala connectivity with the fusiform gyrus, anterior insula, supramarginal gyrus, and precuneus was increased or positively deflected in the patient group. Additionally, the strength rs-FCN between the left amygdala and anterior insula was positively associated with the severity of the fear of negative evaluation in patients with SAD (r = 0.338, p = 0...Continue Reading

References

Jan 1, 1987·Modern Problems of Pharmacopsychiatry·M R Liebowitz
Jun 1, 1996·Computers and Biomedical Research, an International Journal·R W Cox
Apr 8, 1998·Journal of Computer Assisted Tomography·C J HolmesA C Evans
Jul 22, 1998·Behaviour Research and Therapy·R P Mattick, J C Clarke
May 11, 1999·Trends in Cognitive Sciences·R J Davidson, W Irwin
Nov 26, 1999·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·R W Cox, A Jesmanowicz
Sep 29, 2000·The American Journal of Psychiatry·M B Stein, Y M Kean
Nov 7, 2002·Archives of General Psychiatry·Murray B SteinGregory G Brown
Dec 24, 2002·Journal of Cognitive Neuroscience·Ralph AdolphsDaniel Tranel
Dec 31, 2002·Proceedings of the National Academy of Sciences of the United States of America·Michael D GreiciusVinod Menon
Jan 1, 1959·The British Journal of Medical Psychology·M HAMILTON
Jun 1, 1961·Archives of General Psychiatry·A T BECKJ ERBAUGH
May 18, 2004·Brain Research. Brain Research Reviews·Daan BaasRené S Kahn
Aug 2, 2006·Cerebral Cortex·Laura LanteaumeFabrice Bartolomei
Oct 4, 2006·Progress in Brain Research·Ralph Adolphs, Michael Spezio
Jan 20, 2007·Science·Malia F MasonC Neil Macrae
Apr 13, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Michael L SpezioRalph Adolphs
Aug 21, 2007·Nature Reviews. Neuroscience·Michael D Fox, Marcus E Raichle
Apr 1, 2008·Lancet·Murray B Stein, Dan J Stein
Nov 19, 2008·Social Cognitive and Affective Neuroscience·Jillian E HardeeAina Puce
Sep 6, 2011·NeuroImage·Joanne L PowellMarta García-Finaña
Oct 18, 2011·Brain Topography·András JakabErvin L Berényi
Apr 7, 2012·Trends in Cognitive Sciences·Kevin S Weiner, Kalanit Grill-Spector
May 28, 2013·Brain Connectivity·Ziad S SaadRobert W Cox
Aug 21, 2013·Proceedings of the National Academy of Sciences of the United States of America·Stephen J GottsAlex Martin
Apr 29, 2014·Neuroscience and Biobehavioral Reviews·Sebastian OcklenburgOnur Güntürkün
Aug 19, 2014·JAMA Psychiatry·Kathryn R CullenKelvin O Lim
Dec 24, 2014·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Feng LiuHuafu Chen
Jun 5, 2015·PloS One·Stephanie BoehmeThomas Straube
Dec 2, 2015·Journal of Psychiatry & Neuroscience : JPN·Cynthia BinelliRocio Martin-Santos
Dec 25, 2015·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Davide QuarantaGuido Gainotti
Jan 24, 2016·Journal of Psychiatric Research·Soo-Hee ChoiJae-Jin Kim
May 5, 2016·Human Brain Mapping·Jane B AllendorferJerzy P Szaflarski
Jun 23, 2016·Neuropsychologia·Monika S MellemAlex Martin

❮ Previous
Next ❯

Citations

Oct 28, 2019·Neuroreport·Alina O TeterevaOlga V Martynova
Mar 25, 2020·Psychological Medicine·Anne-Kathrin BrehlGuillen Fernández
Jul 2, 2020·Neuropsychiatric Disease and Treatment·Shuhua RanHaitao Li
May 27, 2021·Molecular Psychiatry·Simone MizziIzelle Labuschagne
Jul 21, 2021·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Lorenzo Lucherini AngelettiGeorg Northoff
Jul 27, 2021·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Lei LiQiyong Gong
Aug 12, 2021·Journal of Translational Medicine·Jin CaoJian Kong
Aug 27, 2021·Journal of Psychiatric Research·Ben D A GormanAdam J Guastella
Aug 31, 2021·Neuropharmacology·Samuel W CentanniFrederic W Hopf
Oct 16, 2021·Social Cognitive and Affective Neuroscience·Lisa I HorstmanMarian J Bakermans-Kranenburg

❮ Previous
Next ❯

Methods Mentioned

BETA
SMA

Software Mentioned

Analysis of Functional NeuroImages
ANATICOR
FreeSurfer
PESTICA

Related Concepts

Related Feeds

Brain Circuits in Emotional Learning

The neuronal circuits within the cortico-limbic brain regions form networks that mediate emotional behavior. Areas specific to emotional learning include the basal amygdala and sublenticular extended amygdala region along with a supplemental motor area. Discover the latest research on brain circuits in emotional learning here.

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.

Aphasia

Aphasia affects the ability to process language, including formulation and comprehension of language and speech, as well as the ability to read or write. Here is the latest research on aphasia.