Altered attentional control over the salience network in complex regional pain syndrome

Scientific Reports
Jungyoon KimSujung Yoon

Abstract

The degree and salience of pain have been known to be constantly monitored and modulated by the brain. In the case of maladaptive neural responses as reported in centralized pain conditions such as complex regional pain syndrome (CRPS), the perception of pain is amplified and remains elevated even without sustained peripheral pain inputs. Given that the attentional state of the brain greatly influences the perception and interpretation of pain, we investigated the role of the attention network and its dynamic interactions with other pain-related networks of the brain in CRPS. We examined alterations in the intra- and inter-network functional connectivities in 21 individuals with CRPS and 49 controls. CRPS-related reduction in intra-network functional connectivity was found in the attention network. Individuals with CRPS had greater inter-network connectivities between the attention and salience networks as compared with healthy controls. Furthermore, individuals within the CRPS group with high levels of pain catastrophizing showed greater inter-network connectivities between the attention and salience networks. Taken together, the current findings suggest that these altered connectivities may be potentially associated with the ...Continue Reading

References

Aug 1, 1987·Pain·Ronald Melzack
Nov 1, 1996·Behaviour Research and Therapy·G CrombezP Eelen
Jun 1, 1999·Psychological Bulletin·C Eccleston, G Crombez
Mar 4, 2000·Nature Neuroscience·J B HopfingerG R Mangun
Sep 13, 2000·Neuropsychology Review·R P HartN D Zasler
Apr 6, 2001·The Clinical Journal of Pain·M J SullivanJ C Lefebvre
Apr 24, 2002·Journal of Cognitive Neuroscience·Maurizio CorbettaGordon L Shulman
Aug 10, 2005·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Christian F BeckmannStephen M Smith
May 18, 2007·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·A May
Jun 19, 2007·Brain : a Journal of Neurology·Christian MaihöfnerJörn Schattschneider
Jul 6, 2007·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·R Norman HardenPeter R Wilson
Jul 9, 2008·Trends in Cognitive Sciences·Katja WiechIrene Tracey
Feb 21, 2009·PloS One·Franco CaudaSergio Canavero
Jul 22, 2009·Proceedings of the National Academy of Sciences of the United States of America·Stephen M SmithChristian F Beckmann
May 28, 2010·Arthritis and Rheumatism·Vitaly NapadowRichard E Harris
Jun 1, 2010·Brain Structure & Function·Vinod Menon, Lucina Q Uddin
Jan 3, 2012·Psychosomatic Medicine·Ignacio CifrePedro Montoya
Mar 6, 2013·Arthritis and Rheumatism·Qi WuKaren D Davis
May 31, 2013·Nature Reviews. Neuroscience·M Catherine BushnellLucie A Low
Jun 4, 2013·The Journal of Pain : Official Journal of the American Pain Society·Flavia Di PietroTasha R Stanton
Jun 25, 2013·The Journal of Pain : Official Journal of the American Pain Society·Anne BolwerkChristian Maihöfner
Mar 14, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Aaron KucyiKaren D Davis
Nov 20, 2014·Nature Reviews. Neuroscience·Lucina Q Uddin
Dec 30, 2014·Trends in Neurosciences·Aaron Kucyi, Karen D Davis
Dec 17, 2015·Brain Structure & Function·Kasey S HemingtonKaren D Davis
Feb 10, 2016·Frontiers in Human Neuroscience·Anoop KuttikatChristopher Andrew Brown
Jun 13, 2017·NeuroImage·Arian AshourvanDanielle S Bassett
Jun 11, 2018·Scandinavian Journal of Pain·Norberto BilbenyRodrigo Fernández

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Citations

Apr 7, 2020·The Journal of Bone and Joint Surgery. American Volume·Samantha M MeintsKristin L Schreiber
Aug 14, 2020·Archives of Physical Medicine and Rehabilitation·Jooyeon Jamie ImSujung Yoon
Jun 11, 2021·The Journal of Pain : Official Journal of the American Pain Society·Nicholas J BushJeff Boissoneault
Nov 10, 2021·Scientific Reports·Pauline JahnEnrico Schulz

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