Altered B cell development and anergy in the absence of Foxp3

The Journal of Immunology : Official Journal of the American Association of Immunologists
Steven M LeonardoStephen B Gauld

Abstract

The importance of regulatory T cells in immune tolerance is illustrated by the human immune dysregulatory disorder IPEX (immune dysregulation, polyendocrinopathy, enteropathy, X-linked), caused by a lack of regulatory T cells due to decreased or absent expression of Foxp3. Although the majority of work on regulatory T cells has focused on their ability to suppress T cell responses, the development of significant autoantibody titers in patients with IPEX suggests that regulatory T cells also contribute to the suppression of autoreactive B cells. Using a murine model, deficient in the expression of Foxp3, we show that B cell development is significantly altered in the absence of regulatory T cells. Furthermore, we identify a loss of B cell anergy as a likely mechanism to explain the production of autoantibodies that occurs in the absence of regulatory T cells. Our results suggest that regulatory T cells, by either direct or indirect mechanisms, modulate B cell development and anergy.

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Citations

Mar 21, 2015·International Reviews of Immunology·Héctor Rincón-ArévaloGloria Vásquez
Feb 18, 2016·Stem Cells International·Antonio PieriniRobert S Negrin
Nov 7, 2013·Proceedings of the National Academy of Sciences of the United States of America·Susanne AschermannFalk Nimmerjahn
May 10, 2017·Nature Communications·Antonio PieriniRobert S Negrin
Oct 30, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kea MartinThomas Calzascia
Sep 13, 2014·European Journal of Microbiology & Immunology·Pedro Milanez-AlmeidaJochen Huehn
Mar 29, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yaoyang LiuAntonio La Cava
Jan 7, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Eunkyeong JangJeehee Youn
May 1, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Steven M LeonardoStephen B Gauld
Jan 31, 2017·Journal of Clinical Medicine·Jason S Ellis, Helen Braley-Mullen
Jul 11, 2012·European Journal of Immunology·Steven M LeonardoStephen B Gauld
Sep 26, 2019·Frontiers in Endocrinology·Luise FischerAnnette I Garbe
Apr 9, 2016·The Journal of Allergy and Clinical Immunology·Peter SzodorayBritt Nakken

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