Altered B-cell signaling in lupus

Autoimmunity Reviews
Kui Liu, Chandra Mohan

Abstract

Systemic lupus erythematosus (SLE) is an autoimmune disease of complex etiology primarily characterized by the presence of high titers of autoantibodies targeting many nuclear as well as cytoplasmic antigens, with resultant end-organ damage. Aberrant signaling events have been documented in various lymphocyte populations, and they have constituted attractive targets for therapeutic intervention. Murine models of lupus (conventional or engineered) have yielded interesting snapshots of the signaling status of lupus lymphocytes, and many of these alterations in cell signaling observed in murine models of lupus have also been documented in patient samples. Analyses of B-cell signaling in various murine lupus models have not only provided an in-depth perspective of the signaling status and possibly the underlying mechanisms leading to enhanced survival of autoimmune B cells, but have also presented us with potential strategies for treating lupus.

References

May 23, 1998·Annual Review of Immunology·T J Vyse, B L Kotzin
Jun 22, 1999·The Journal of Clinical Investigation·C MohanE K Wakeland
Sep 25, 1999·Science·A Di CristofanoP P Pandolfi
Dec 10, 1999·The Journal of Experimental Medicine·F MackayJ L Browning
Mar 21, 2000·Rheumatology·M C Pickering, M J Walport
Jun 7, 2000·Proceedings of the National Academy of Sciences of the United States of America·L MorelE K Wakeland
Apr 6, 2001·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·S N LiossisP P Sfikakis
Sep 25, 2001·Immunity·E K WakelandT W Behrens
Oct 31, 2001·Clinical Immunology : the Official Journal of the Clinical Immunology Society·E J EnyedyG C Tsokos
Apr 27, 2002·Nature·Ingrid MecklenbräukerAlexander Tarakhovsky
Jun 1, 2002·Science·Stephen B GauldJohn C Cambier
Nov 7, 2002·Journal of Autoimmunity·Joseph M TuscanoM Eric Gershwin
Nov 5, 2003·Trends in Immunology·Betty P Tsao
Jun 8, 2004·Arthritis Research & Therapy·Amrie C Grammer, Peter E Lipsky
Oct 30, 2004·Current Opinion in Immunology·Swapan K NathJohn B Harley
Jun 15, 2005·Critical Reviews in Immunology·Gyorgy NagyAndras Perl
Jun 17, 2006·Proceedings of the National Academy of Sciences of the United States of America·Srividya SubramanianEdward K Wakeland
Aug 23, 2006·The Journal of Experimental Medicine·Meggan MackayBetty Diamond
Jul 21, 2007·The Journal of Clinical Investigation·Tianfu WuChandra Mohan
Oct 6, 2007·Immunologic Research·Frederick W Quelle
Jan 15, 2008·Autoimmunity Reviews·José C Crispín, George C Tsokos
Jan 22, 2008·The New England Journal of Medicine·Geoffrey HomTimothy W Behrens
Mar 28, 2008·Nature Genetics·Sergey V KozyrevMarta E Alarcón-Riquelme

❮ Previous
Next ❯

Citations

Sep 2, 2011·EMBO Molecular Medicine·Barry G GarchowMarianthi Kiriakidou
Jun 25, 2009·Current Opinion in Rheumatology·Andras PerlPaul E Phillips
Aug 19, 2010·Autoimmunity Reviews·Carlo Selmi
Oct 27, 2009·Autoimmunity Reviews·Patrick S C LeungMi-Hua Tao
Mar 25, 2009·Journal of Autoimmunity·Pierre Youinou, Christophe Jamin
May 25, 2013·European Journal of Clinical Investigation·Taher E TaherRizgar A Mageed
Mar 6, 2010·Journal of Internal Medicine·F PerosaF Dammacco
Nov 14, 2015·Science China. Life Sciences·LiDan ZhaoXuan Zhang
Apr 7, 2010·International Reviews of Immunology·Heather M Seitz, Glenn K Matsushima
Mar 5, 2014·Expert Opinion on Pharmacotherapy·Stamatis-Nick C Liossis, Konstantinos Melissaropoulos
Mar 6, 2015·Current Pediatrics Reports·Kazumoto IijimaKandai Nozu
Apr 20, 2016·F1000Research·Moin A Saleem, Yasuko Kobayashi
Mar 26, 2010·Expert Opinion on Therapeutic Targets·Daoxin MaMing Hou
Jun 29, 2016·Clinical & Translational Immunology·Shereen OonIan Wicks
May 14, 2017·Clinical Reviews in Allergy & Immunology·Patrice HemonOlivier Mignen

❮ Previous
Next ❯

Related Concepts

Related Feeds

B cell Activation

B cell activation is initiated by the ligation of the B cell receptor with antigen and ultimately results in the production of protective antibodies against potentially pathogenic invaders. Here is the latest research.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.

© 2022 Meta ULC. All rights reserved