Altered balance of functional brain networks in Schizophrenia

Psychiatry Research. Neuroimaging
Todd S WoodwardKatie M Lavigne

Abstract

Activity in dorsal attention (DAN) and frontoparietal (FPN) functional brain networks is linked to allocation of attention to external stimuli, and activity in the default-mode network (DMN) is linked to allocation of attention to internal representations. Tasks requiring attention to external stimuli shift activity to the DAN/FPN and away from the DMN, and optimal task performance depends on balancing DAN/FPN against DMN activity. The current functional magnetic resonance imaging (fMRI) study assessed the balance of DAN/FPN and DMN activity in 13 schizophrenia patients and 13 healthy controls while they were engaged in a task switching Stroop paradigm which demanded internally directed attention to task instructions. The typical pattern of reciprocity between the DAN/FPN and DMN was observed for healthy controls but not for patients, suggesting a reduction in the internally focussed thought important for maintenance of instructions and strategies in schizophrenia. The observed alteration in the balance between DAN/FPN and DMN in patients may reflect a general mechanism underlying multiple forms of cognitive impairment in schizophrenia, including global processing deficits such as cognitive inefficiency and impaired context pro...Continue Reading

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Citations

Aug 2, 2016·Human Brain Mapping·Katie M LavigneTodd S Woodward
Nov 7, 2019·Journal of Neuroscience Research·Brian D BermanJason R Tregellas
May 6, 2019·Schizophrenia Bulletin·Katie M LavigneTodd S Woodward
Jul 16, 2021·Journal of the American Statistical Association·Joshua LukemireYing Guo
Jul 26, 2021·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Meighen M RoesTodd S Woodward

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