Altered baroreflex and autonomic modulation in monosodium glutamate-induced hyperadipose rats

Metabolism: Clinical and Experimental
Marlusa Karlen-AmaranteMarli Cardoso Martins-Pinge

Abstract

We aimed to examine the cardiovascular function by tonic and baroreflex alterations in obese rats induced by monosodium glutamate (MSG). Neonatal male Wistar rats were injected with MSG (4 mg/g body weight) or equimolar saline (control, C). At 90 days, all rats were anesthetized for catheterization of the femoral artery for mean arterial pressure (MAP) and heart rate (HR) recordings in the conscious state. After baseline, we performed IV treatment with hexamethonium (25 mg/kg), or atropine (1 mg/kg) or propranolol (3 mg/kg). We also performed the spectral analysis of heart rate variability (HRV) and baroreflex sensitivity. Baseline comparison showed that obese rats are hypertensive compared with control (C=110±2 mmHg; MSG=: 123±3 mmHg, P<0.05). After ganglionic blockade with hexamethonium the differences in MAP between control and obese rats disappeared. Beta adrenergic blockade with propranolol induced a greater decrease in heart rate compared with control. The analysis of HRV showed that obese rats have increased modulation by both components of the autonomic nervous system compared with control rats. The baroreflex gain showed increased sensitivity for the parasympathetic component in the obese rats (C=-2.41±0.25; MSG=-3.34±...Continue Reading

References

Aug 1, 1991·Circulation·A MallianiS Cerutti
Oct 1, 1983·Journal of the Autonomic Nervous System·F Rohner-JeanrenaudB Jeanrenaud
May 1, 1997·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·A E HirataM S Dolnikoff
May 29, 1999·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·V M FarahE M Krieger
Apr 25, 2001·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·M DolnikoffE Herrera
Jan 20, 2004·Journal of Applied Physiology·K De AngelisM C Irigoyen
Jan 30, 2004·Recent Progress in Hormone Research·Ashish AnejaJames R Sowers
Sep 6, 2005·Autonomic Neuroscience : Basic & Clinical·Marli Cardoso Martins-PingeOswaldo Ubríaco Lopes
Jun 20, 2006·Regulatory Peptides·Lenka MaletínskáBlanka Zelezná
Sep 5, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Helio C SalgadoRubens Fazan
Nov 23, 2006·Hypertension·Cyndya ShibaoItalo Biaggioni
Dec 13, 2006·Acta Cirúrgica Brasileira·Vinicius Von DiemenManoel Roberto Maciel Trindade
Feb 6, 2007·Transplantation Proceedings·P C de Freitas MathiasC Gravena
Aug 21, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Ann M SchreihoferDavid W Stepp
Oct 4, 2007·Experimental Physiology·John F B MorrisonEric Mensah-Brown
Feb 16, 2008·Autonomic Neuroscience : Basic & Clinical·Hugo C D SouzaGeisa C S V Tezini
Mar 1, 2008·Clinical and Experimental Pharmacology & Physiology·Margaret J Morris
Mar 18, 2008·Arquivos brasileiros de endocrinologia e metabologia·Alina F VolteraOsvaldo Kohlmann
Aug 13, 2008·Current Opinion in Nephrology and Hypertension·Pantelis A Sarafidis
Feb 25, 2009·Hypertension·Patrick MathieuJean-Pierre Després
Mar 20, 2009·Autonomic Neuroscience : Basic & Clinical·Samantha Bagolan de AbreuMarli Cardoso Martins-Pinge
May 16, 2009·Current Hypertension Reports·Alexandre A da SilvaJohn E Hall
Mar 10, 2010·The Journal of Physiology·Domitila A Huber, Ann M Schreihofer
Dec 9, 2010·Neuroscience Letters·Marcelo Franchini GiustiEduardo Colombari
Aug 10, 2011·Autonomic Neuroscience : Basic & Clinical·Natália Veronez da CunhaMarli Cardoso Martins-Pinge
Nov 22, 2011·Obesity Surgery·Amaia RodríguezGema Frühbeck

❮ Previous
Next ❯

Citations

Jun 19, 2012·Neuroscience Letters·Alexandro Márcio da Silva MattosMarli Cardoso Martins-Pinge
Sep 27, 2015·Neuroscience Letters·Deborah ArizaMarli Cardoso Martins-Pinge
Nov 28, 2013·Journal of the American Geriatrics Society·Magali Saint MartinUNKNOWN PROOF Study Group
Apr 27, 2016·The Journal of Endocrinology·Rosiane A MirandaPaulo C F Mathias
Dec 10, 2016·Journal of Developmental Origins of Health and Disease·R Vidal-SantosV J Santana-Filho
Jan 6, 2017·Clinical and Experimental Hypertension : CHE·Natalia Veronez da CunhaMarli Cardoso Martins-Pinge
Mar 19, 2014·American Journal of Physiology. Heart and Circulatory Physiology·Natalia Veronez da CunhaMarli Cardoso Martins-Pinge
Apr 3, 2020·Environmental Science and Pollution Research International·Suzan M HazzaaGhada E Elgarawany

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bradyarrhythmias

Bradyarrhythmias are slow heart rates. Symptoms may include syncope, dizziness, fatigure, shortness of breath, and chest pains. Find the latest research on bradyarrhythmias here.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.