Altered binding of serum thyroid hormone to thyroxine-binding globulin in women with functional hypothalamic amenorrhea

Fertility and Sterility
C E DominguezS S Yen

Abstract

To further characterize hypothyroidemia with decreased serum concentrations of total triiodothyronine and total T4 in women with functional hypothalamic amenorrhea. Cohort study. University of California San Diego Clinical Research Center. 8 women with functional hypothalamic amenorrhea (hypogonadotropic or normogonadotropic amenorrhea of at least 6 months duration) and 9 normal cycling women in the early follicular phase of their cycles. 24-hour frequent blood sampling. Comparison of levels of thyroid hormones and binding proteins between functional hypothalamic amenorrhea and normal cycling women. Measurements of serum free T4, free triiodothyronine, total T4, total triiodothyronine, reverse triiodothyronine, thyroid-binding globulin, albumin, and prealbumin levels and determination of T4 binding and binding affinity to each of the three binding proteins. The results confirmed reduced levels of total triiodothyronine and total T4, but revealed no significant difference in free triiodothyronine and free T4, as well as reverse triiodothyronine, levels between functional hypothalamic amenorrhea and normal cycling women. Although serum levels of thyroid hormone-binding proteins were similar between normal cycling women and functi...Continue Reading

References

Jul 1, 1975·The Journal of Clinical Endocrinology and Metabolism·A G VagenakisL E Braverman
Jan 1, 1991·The Journal of Clinical Endocrinology and Metabolism·J S LoPrestiJ T Nicoloff
Feb 1, 1989·The Journal of Clinical Endocrinology and Metabolism·S L BergaS S Yen
Aug 1, 1989·Endocrine Reviews·S Refetoff
Jan 1, 1988·The Journal of Clinical Endocrinology and Metabolism·S L BergaS S Yen
Apr 1, 1988·The Journal of Clinical Endocrinology and Metabolism·B Y SuhS S Yen
May 1, 1985·The Journal of Clinical Endocrinology and Metabolism·I J ChopraD H Solomon
Jun 1, 1972·The Journal of Clinical Endocrinology and Metabolism·S W Spaulding, R I Gregerman
Apr 1, 1984·The Journal of Clinical Endocrinology and Metabolism·I J ChopraD H Solomon

❮ Previous
Next ❯

Citations

Feb 22, 2001·Journal of Psychosomatic Research·K A GendallF A Carter
Feb 26, 2000·Thyroid : Official Journal of the American Thyroid Association·R WangR B Wilcox
Apr 28, 2004·ILAR Journal·Jay R Kaplan, Stephen B Manuck
Oct 14, 2017·Current Osteoporosis Reports·Mary Jane De SouzaEmily A Southmayd

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.