PMID: 2115301Jul 1, 1990Paper

Altered blood flow regulation in autotransplanted pancreatic islets of rats

The American Journal of Physiology
L Jansson, S Sandler

Abstract

Adult rats were partially depancreatized, and approximately 500 islets were isolated from each excised pancreas, maintained in tissue culture for 7 days, and subsequently transplanted back to the same animals beneath the renal capsule. Four weeks after transplantation the animals were anesthetized and given an intravenous injection of 1 ml of either saline, 30% (wt/vol) D-glucose, 30% (wt/vol) D-galactose, DL-propranolol (15 mg/kg body wt) dissolved in saline, or terbutaline (1 mg/kg body wt) dissolved in saline. Five minutes later blood perfusion of the islet grafts and the pancreatic remnant were measured with a microsphere technique. Islet blood flow was also measured in animals with pancreas intact and no islet grafts after administration of saline, glucose, or galactose. These animals demonstrated a significant and preferential increase in islet blood flow after glucose administration, whereas galactose caused a selective decrease in islet blood perfusion. Both whole pancreatic blood flow and islet blood flow in the pancreatic remnant were decreased by terbutaline administration, whereas the other substances had no effect. Blood flow to the transplanted islets was decreased by glucose and galactose, whereas propranolol and...Continue Reading

References

Mar 1, 1977·Diabetes·R C GriffithP E Lacy
Jul 1, 1978·Proceedings of the Society for Experimental Biology and Medicine·E J ZambraskiG F DiBona
Jul 1, 1988·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·R L Jirtle
Feb 1, 1973·The Biochemical Journal·S J AshcroftP J Randle
Jul 1, 1983·Diabetologia·L Jansson, C Hellerström

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