Altered bone-regulating myokine expression in skeletal muscle Of Duchenne muscular dystrophy mouse models

Muscle & Nerve
Shumin ZhouHongshuai Li

Abstract

Duchenne muscular dystrophy (DMD) has been well characterized as a disease that affects both skeletal muscle and bone. The pathophysiology responsible for the deficits in bone tissue is still unclear. Quantitative reverse-transcription polymerase chain reaction and Western blot analyses of known myokines from skeletal muscle were performed on dystrophic mouse models and wild-type (WT) controls to identify differentially expressed bone-regulating myokines. Twenty-four of 43 myokine genes demonstrated significantly different mRNA expression in the skeletal muscles of dystrophic mice when compared with muscles of WT mice. Several differently expressed bone-regulating myokine genes were identified, and their protein levels were also verified by Western blot. Dystrophic skeletal muscle demonstrated a significantly altered myokine gene expression profile. mRNA and protein levels of several bone-regulating myokines were significantly altered in dystrophic skeletal muscle, which suggests pathological role of bone-regulating myokines on bone homeostasis in DMD. Muscle Nerve 58: 573-582, 2018.

References

Mar 1, 1977·The Journal of Trauma·I M Siegel
Mar 1, 1990·Endocrinology·L R ReidT J Martin
Aug 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·D Metcalf, D P Gearing
Jan 1, 1973·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·M A ArianoV R Edgerton
Mar 1, 1993·Endocrinology·J CornishI R Reid
May 1, 1996·Biochemical Society Transactions·S J Winder
Jan 21, 2000·Journal of Pediatric Orthopedics·C M Larson, R C Henderson
Oct 12, 2000·Cytokine·D Heymann, A V Rousselle
Jul 19, 2001·Proceedings of the National Academy of Sciences of the United States of America·S J Lee, A C McPherron
Sep 11, 2002·Neuromuscular Disorders : NMD·Marina BakayEric P Hoffman
Nov 5, 2002·Proceedings of the National Academy of Sciences of the United States of America·Judith N HaslettLouis M Kunkel
Dec 3, 2002·Nature·Sasha BogdanovichTejvir S Khurana
Jun 13, 2003·Clinical Pediatrics·J E BothwellS Salisbury
Oct 8, 2003·Acta Neuropathologica·Manuel RoigFrancina Munell
Mar 26, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Sasha BogdanovichTejvir S Khurana
Feb 24, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Mark W HamrickJohn McCormick
Feb 21, 2008·Clinica Chimica Acta; International Journal of Clinical Chemistry·Hiroyuki AwanoMasafumi Matsuo
Oct 25, 2008·FEBS Letters·Yasuhiro IzumiyaKenneth Walsh
Feb 19, 2009·Physiological Genomics·Mario MarottaManuel Roig-Quilis
Sep 2, 2009·Diabetes·Pernille HojmanBente Klarlund Pedersen
Dec 1, 2009·Lancet Neurology·Katharine BushbyUNKNOWN DMD Care Considerations Working Group
Jul 27, 2010·Human Molecular Genetics·Henna TyynismaaAnu Suomalainen
Apr 22, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Anna RufoAnna Teti
Feb 9, 2012·Proceedings of the National Academy of Sciences of the United States of America·Wei WeiYihong Wan
Oct 26, 2012·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Christian IsaacJohnny Huard
Jan 31, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Tizhong ShanShihuan Kuang
May 15, 2013·The FEBS Journal·Pura Muñoz-CánovesAntonio L Serrano
Jan 1, 2012·BoneKEy Reports·Victor H MorgenrothPaula R Clemens
Jan 28, 2014·Journal of Cellular Biochemistry·Kenta MatsushitaMikako Hayashi
Mar 19, 2014·The Journal of Clinical Endocrinology and Metabolism·J C RousseauP Garnero
May 23, 2014·The EMBO Journal·José J Fuster, Kenneth Walsh
Jul 8, 2014·European Journal of Histochemistry : EJH·M KammounB Picard

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Citations

Jun 13, 2019·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Sung-Hee YoonJane Mitchell
Dec 5, 2019·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Hongshuai LiLing Wang
Apr 8, 2021·Cellular and Molecular Life Sciences : CMLS·Alicja Starosta, Patryk Konieczny
Apr 16, 2021·Frontiers in Genetics·Catherine L Omosule, Charlotte L Phillips
May 1, 2021·Metabolites·Hongshuai LiJohnny Huard
Jan 25, 2022·The FEBS Journal·Rachel J Waldemer-StreyerJie Chen

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