Altered brain activation in dorsolateral prefrontal cortex in adolescents and young adults at genetic risk for schizophrenia: an fMRI study of working memory

Schizophrenia Research
Larry J SeidmanMing T Tsuang

Abstract

Adult first-degree relatives of persons with schizophrenia carry elevated genetic risk for the illness, demonstrate working memory (WM) impairments, and manifest alterations in dorsolateral prefrontal cortical (DLPFC) function during WM. Because substantially less is known about these phenotypes in adolescent subjects we sought to demonstrate that young relatives of persons with schizophrenia manifest impaired WM and altered prefrontal activation. Participants were 21 non-psychotic, unmedicated first-degree relatives of persons with a DSM-IV diagnosis of schizophrenia or schizoaffective disorder, depressed type and 24 unmedicated controls, recruited from the community and hospitals in metropolitan Boston (ages 13-28). We compared groups on an auditory WM task with interference prior to scanning and used functional magnetic resonance imaging (fMRI) to compare groups while performing visual 2-back WM and control vigilance tasks. Blood oxygen level dependent signal change was measured using two whole-brain gradient echo EPI pulse acquisitions (21 contiguous, 5mm axial slices), acquired on a Siemens 1.5T MR scanner. Data were analyzed using Statistical Parametric Mapping-99. The high risk subjects were significantly impaired on the...Continue Reading

Citations

Mar 15, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Bing LiuTianzi Jiang
May 17, 2007·Schizophrenia Bulletin·William S Stone, Larry J Seidman
Jul 23, 2008·Schizophrenia Bulletin·Laura K Phillips, Larry J Seidman
Jan 24, 2009·Proceedings of the National Academy of Sciences of the United States of America·Susan Whitfield-GabrieliLarry J Seidman
May 15, 2012·Psychological Medicine·E B LiddleP F Liddle
Aug 3, 2007·International Review of Psychiatry·Heather C WhalleyStephen M Lawrie
Jan 31, 2015·Journal of Clinical Child and Adolescent Psychology : the Official Journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53·Natalie L ColichIan H Gotlib
Sep 15, 2015·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Emanuel SchwarzAndreas Meyer-Lindenberg
Dec 3, 2010·Schizophrenia Research·Matcheri S KeshavanLarry J Seidman
Jan 1, 2008·Journal of Affective Disorders·H C WhalleyA M McIntosh
Jul 17, 2007·Biological Psychiatry·Zainab DelawallaDeanna M Barch
Jan 16, 2007·Neuroscience and Biobehavioral Reviews·Paolo Fusar-PoliPhilip McGuire
Feb 20, 2007·Schizophrenia Research·Xiaobo LiLynn E DeLisi
Nov 27, 2008·Acta Psychiatrica Scandinavica·A M McIntoshS M Lawrie
Oct 29, 2011·Early Intervention in Psychiatry·Siow-Ann ChongRichard S E Keefe
Nov 25, 2006·Biological Psychiatry·Aaron Bonner-JacksonDeanna M Barch
Aug 13, 2013·Schizophrenia Research·Benjamin K BrentMatcheri S Keshavan
Jul 15, 2015·Schizophrenia Research·T C ManschreckL J Seidman
Feb 26, 2014·NeuroImage. Clinical·C A MontojoC E Bearden
Aug 25, 2012·Journal of the American Academy of Child and Adolescent Psychiatry·Marinos KyriakopoulosSophia Frangou
Dec 14, 2011·Progress in Neuro-psychopharmacology & Biological Psychiatry·Sung Nyun KimJun Soo Kwon
Sep 25, 2012·Schizophrenia Research·Min Soo ByunJun Soo Kwon

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