Altered brain activity processing in high-anxiety rodents revealed by challenge paradigms and functional mapping

Neuroscience and Biobehavioral Reviews
Nicolas Singewald

Abstract

Pathological anxiety involves aberrant processing of emotional information that is hypothesized to reflect perturbations in fear/anxiety pathways. The affected neurobiological substrates in patients with different anxiety disorders are just beginning to be revealed. Important leads for this research can be derived from findings obtained in psychopathologically relevant rodent models of enhanced anxiety, by revealing where in the brain neuronal processing in response to diverse challenges is different to that in animals with lower anxiety levels. Different functional mapping methods in various rodent models, including psychogenetically selected lines or genetically modified animals, have been used for this purpose. These studies show that the divergent anxiety-related behavioral response of high-anxiety- vs. normal and/or low-anxiety rodents to emotional challenges is associated with differential neuronal activation in restricted parts of proposed fear/anxiety circuitries including brain areas thought to be important in stress, emotion and memory. The identification of neuronal populations showing differential activation depends in part on the applied emotional challenge, indicating that specific facets of elicited fear or anxie...Continue Reading

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Oct 5, 2010·Psychopharmacology·Siobhain M O'MahonyJohn F Cryan
Aug 5, 2009·Molecular Neurobiology·Katie J McLaughlinCheryl D Conrad
Jan 18, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Claudia SchmuckermairNicolas Singewald
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