Altered Brain Functional Network in Parkinson Disease With Rapid Eye Movement Sleep Behavior Disorder

Frontiers in Neurology
Jiao LiGuanxun Cheng

Abstract

Background and Objective: Parkinson disease (PD) with rapid eye movement (REM) sleep behavior disorder (PD-RBD) tend to be a distinct phenotype with more severe clinical characteristics and pathological lesion when compared with PD without RBD (PD-nRBD). However, the pathological mechanism underlying PD-RBD remains unclear. We aim to use the resting-state functional magnetic resonance imaging (rs-fMRI) to explore the mechanism of PD-RBD from the perspective of internal connectivity networks. Materials and Methods: A total of 92 PD patients and 20 age and sex matched normal controls (NC) were included. All participants underwent rs-fMRI scan and clinical assessment. According to the RBD screening questionnaire (RBDSQ), PD patients were divided into two groups: PD with probable RBD (PD-pRBD) and PD without probable RBD (PD-npRBD). The whole brain was divided into 90 regions using automated anatomic labeling atlas. Functional network of each subject was constructed according to the correlation of rs-fMRI blood oxygenation level dependent signals in any two brain regions and network metrics were analyzed using graph theory approaches. Network properties among three groups were compared and correlation analysis was made using distin...Continue Reading

References

Oct 30, 2001·Behavioural Brain Research·Y BenjaminiI Golani
Mar 15, 2003·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Erzsébet Ravasz, Albert-László Barabási
Jun 12, 2003·Trends in Neurosciences·A D Craig
Dec 13, 2006·Neurology·Lewis Sudarsky, Joseph Friedman
Sep 27, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Karin Stiasny-KolsterWolfgang H Oertel
Jan 25, 2008·Journal of Neurology·Marie-Helene MarionOliver Foster
Jan 22, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Chris C TangDavid Eidelberg
Jul 16, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mary-Ellen LynallEd Bullmore
Jan 1, 2011·Brain Connectivity·Qawi K TelesfordPaul J Laurienti
Feb 1, 2013·Neuropathology and Applied Neurobiology·M E KalaitzakisR K B Pearce
Mar 2, 2013·Movement Disorders : Official Journal of the Movement Disorder Society·Andrew H FordJohn T O'Brien
Jul 8, 2014·Parkinsonism & Related Disorders·M SalsoneA Quattrone
Apr 24, 2015·Lancet·Lorraine V Kalia, Anthony E Lang
May 2, 2015·Journal of Neurology·Chun Yan LuoHui-Fang Shang
Dec 19, 2015·Parkinsonism & Related Disorders·Jae-Sung LimYu Kyeong Kim
Mar 25, 2016·Parkinsonism & Related Disorders·L M ChahineD Weintraub
Apr 12, 2016·Journal of Alzheimer's Disease : JAD·Hee-Jin KimWon-Jin Moon
Feb 7, 2017·Movement Disorders : Official Journal of the Movement Disorder Society·Cecile GalleaMarie Vidailhet
Nov 25, 2017·Nature Reviews. Neurology·Birgit HöglAleksandar Videnovic
Feb 25, 2018·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Sanne K MelesUNKNOWN REMPET Study Group
Aug 30, 2018·Brain Imaging and Behavior·Sanne KampsChris Vriend
Sep 1, 2018·Nature Reviews. Disease Primers·Yves DauvilliersBradley Boeve
Dec 7, 2019·Translational Neurodegeneration·Xiaojun GuanMin-Ming Zhang

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Citations

Nov 20, 2021·Frontiers in Computational Neuroscience·Chenggang SongYiqian Tang

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