Altered brain structure and function associated with sensory and affective components of classic trigeminal neuralgia

Pain
Yuan WangMing Zhang

Abstract

Classic trigeminal neuralgia (CTN) is a chronic neuropathic pain state characterized by intense, piercing spasms of the orofacial region, and may be attributable to abnormal pain processing in the central nervous system. Our study investigated neuronal alterations using voxel-based morphometry (VBM), diffuse tensor imaging (DTI), and resting-state functional connectivity in 38 patients with CTN and 38 matched healthy controls. For voxel-based morphometry analyses, patients with CTN displayed gray matter volume (GMV) reductions in the anterior-cingulate cortex (ACC) and mid-cingulate cortex, insula, secondary somatosensory cortex (S2), primary motor cortex (M1), premotor area, and several regions in the temporal lobe. For DTI analysis, patients compared with controls had increased mean diffusivity (MD) and decreased fractional anisotropy (FA) in the corpus callosum and the bilateral corona radiata, and increased mean diffusivity with no fractional anisotropy changes across the bilateral superior longitudinal fasciculus, the internal and external capsule, the thalamus and brainstem. Additionally, patients with CTN had enhanced functional connectivity between the right insula/S2 and ACC, medial prefrontal cortex, posterior cingula...Continue Reading

References

Nov 1, 1984·Archives of Neurology·G H FrommJ C Maroon
Apr 12, 2003·Brain : a Journal of Neurology·J LorenzK L Casey
Dec 3, 2003·Radiology·Setsu WakanaSusumu Mori
Jul 5, 2005·Nature Reviews. Neuroscience·Brent A Vogt
Apr 21, 2006·NeuroImage·Stephen M SmithTimothy E J Behrens
Apr 25, 2006·Journal of Oral Rehabilitation·B J Sessle
Dec 7, 2006·Pain Practice : the Official Journal of World Institute of Pain·Thomas TölleAlesia Sadosky
Jan 27, 2007·BMJ : British Medical Journal·Luke BennettoGeraint Fuller
Feb 23, 2007·Journal of Neurophysiology·David A Seminowicz, Karen D Davis
Feb 23, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Marie AvillacJean-René Duhamel
Oct 20, 2007·Cephalalgia : an International Journal of Headache·M B Vincent, N Hadjikhani
Feb 8, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Marwan N BalikiDante R Chialvo
Apr 15, 2009·Human Brain Mapping·Maria BlatowChristoph Stippich
May 21, 2009·Nature Reviews. Neuroscience·Amy F T Arnsten
May 28, 2010·Arthritis and Rheumatism·Vitaly NapadowRichard E Harris
Jun 1, 2010·Brain Structure & Function·Vinod Menon, Lucina Q Uddin
Jul 9, 2010·European Journal of Pain : EJP·Xavier MoissetDidier Bouhassira
Aug 14, 2010·Pain·Cheng-Hao TuJen-Chuen Hsieh
Dec 15, 2010·The Journal of Pain : Official Journal of the American Pain Society·Michael E RobinsonRoland Staud
Feb 19, 2011·Nature Reviews. Neuroscience·Alexander J ShackmanRichard J Davidson
May 20, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·David A SeminowiczLaura S Stone
Oct 25, 2011·PloS One·Marwan N BalikiA Vania Apkarian
Dec 2, 2011·Human Brain Mapping·Emma G Duerden, Marie-Claire Albanese
Apr 17, 2012·Brain Research·Massieh MoayediKaren D Davis
Jul 25, 2012·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Karen D Davis, Massieh Moayedi
Feb 9, 2013·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Roland IvoBernd Weber
Mar 15, 2013·NeuroImage·Mark ObermannZaza Katsarava
Apr 12, 2013·The New England Journal of Medicine·Tor D WagerEthan Kross
May 31, 2013·Nature Reviews. Neuroscience·M Catherine BushnellLucie A Low
Jun 19, 2013·Cephalalgia : an International Journal of Headache·UNKNOWN Headache Classification Committee of the International Headache Society (IHS)
Mar 14, 2014·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Michael W ColeAlan Anticevic

❮ Previous
Next ❯

Citations

Jan 18, 2018·The Journal of Headache and Pain·Wei-Ta ChenShuu-Jiun Wang
Aug 9, 2018·Cephalalgia : an International Journal of Headache·Yuan WangMing Zhang
May 23, 2018·Psychosomatic Medicine·Stefano MagonMichael Noll-Hussong
Aug 20, 2020·The New England Journal of Medicine·Giorgio CruccuAndrea Truini
May 23, 2019·Frontiers in Neurology·Hui XuYuan Wang
Jan 8, 2020·Molecular Pain·Eder GambetaGerald W. Zamponi
Jun 8, 2018·Molecular Neurobiology·Wei-Yi OngDeron R Herr
Dec 18, 2020·Frontiers in Human Neuroscience·Laura Torrecillas-MartínezPablo Galindo-Moreno
Mar 2, 2021·Frontiers in Neurology·Hayden DanylukTejas Sankar
Mar 19, 2021·Journal of Pain Research·Xiang-Xin XingJian-Guang Xu
Sep 15, 2020·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Sander De GrooteMaarten Moens
Jun 7, 2021·Neuroscience and Biobehavioral Reviews·Anne Margarette S MaalloScott A Holmes
Jun 5, 2021·NeuroImage. Clinical·Peter Shih-Ping HungMojgan Hodaie
Aug 13, 2021·Scientific Reports·Meng LiGuihua Jiang
Jul 22, 2021·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Dan LiYuan Wang
Jan 1, 2020·Neurobiology of Pain·S A HolmesD Borsook

❮ Previous
Next ❯

Related Concepts

Related Feeds

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Barrel cortex

Here is the latest research on barrel cortex, a region of somatosensory and motor corticies in the brain, which are used by animals that rely on whiskers for world exploration.