Altered breast development in young girls from an agricultural environment

Environmental Health Perspectives
E A GuilletteLouis J Guillette

Abstract

In several human populations, the age at which female breast development begins is reported to have declined over the last five decades. Much debate has occurred over whether this reported decline has actually occurred and what factors contribute to it. However, geographical patterns reflecting earlier developmental onset in some human populations suggest environmental factors influence this phenomenon. These factors include interactions between genetic makeup, nutrition, and possible cumulative exposure to estrogens, both endogenous as well as environmental beginning during in utero development. We examined the onset of breast development in a group of peripubertal girls from the Yaqui Valley of Sonora, Mexico. We observed that girls from valley towns, areas using modern agricultural practices, exhibited larger breast fields than those of girls living in the foothills who exhibited similar stature [e.g., weight, height, body mass index (BMI)], and genetic background. Further, girls from valley towns displayed a poorly defined relationship between breast size and mammary gland development, whereas girls from the Yaqui foothills, where traditional ranching occurs, show a robust positive relationship between breast size and mamma...Continue Reading

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Citations

Jul 17, 2008·Environmental Health : a Global Access Science Source·Tanja KrügerEva C Bonefeld-Jorgensen
Dec 6, 2008·Environmental Health Perspectives·Krista A McCoyColette M St Mary
Dec 14, 2007·Molecular Reproduction and Development·Tanja KrügerEva C Bonefeld-Jorgensen
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Jul 24, 2012·The Science of the Total Environment·Maria M Meza-MontenegroDiana Meza-Figueroa
Apr 17, 2009·Environmental Science & Technology·Frances OrtonEdwin J Routledge

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