PMID: 3755953Jul 1, 1986Paper

Altered calcium signal transduction after chronic ethanol consumption

Alcohol
R A RiusM Trabucchi

Abstract

Calcium and calcium-calmodulin dependent phosphorylation of several protein bands was found altered in synaptosomal membranes prepared from ethanol treated rats. The ethanol induced effect on Ca++ and Ca++-calmodulin phosphorylation presented regional differences. In particular 32P incorporation was lower in the striatum and cerebellum, higher in the hippocampus and unmodified in the cortex. Part of the phosphorylated bands had an apparent molecular weight similar to that of the phosphoproteins involved in neurotransmission. These results extend previous observations indicating that calcium movement control is modified during chronic ethanol consumption and suggest that ethanol may interfere at various steps in the calcium-promoted events.

References

Jan 13, 1978·Science·P Greengard
Jan 1, 1979·Pharmacology, Biochemistry, and Behavior·J M Wood, R Laverty
Jul 1, 1979·Biochemical Pharmacology·E K Michaelis, S L Myers
Jun 5, 1975·Analytical Biochemistry·J J Witt, R Roskoski
Mar 15, 1983·Biochemical Pharmacology·M L Michaelis, E K Michaelis
Oct 13, 1983·Nature·E J Nestler, P Greengard
Jan 1, 1983·Pharmacology, Biochemistry, and Behavior·M L MichaelisT Tehan
Sep 21, 1984·Science·E J NestlerP Greengard
May 1, 1983·Journal of Neurochemistry·R G Sorensen, H R Mahler
May 1, 1982·Biochemical Pharmacology·R A Harris, D Fenner
Jun 15, 1982·Biochemical and Biophysical Research Communications·K von Hungen, C F Baxter

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.