Dec 1, 1987

Altered calmodulin activity in buccal epithelial cells from cystic fibrosis patients

Clinica Chimica Acta; International Journal of Clinical Chemistry
M A McPhersonM C Goodchild


Boiled extracts of buccal epithelial cells from control subjects and cystic fibrosis patients were shown to possess calmodulin like activity, as assessed by their ability to activate calmodulin-deficient cyclic AMP phosphodiesterase. Estimation of calmodulin content, using pure calmodulin as standard revealed that control extracts contained 3.08 +/- 0.71 SEM (n = 7) micrograms calmodulin/mg protein and cystic fibrosis extracts 0.88 +/- 0.30 SEM (n = 12) micrograms calmodulin/mg protein (p less than 0.02 for difference from control). The results indicate that the biological activity of calmodulin is altered in buccal epithelial cells from cystic fibrosis individuals.

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Mentioned in this Paper

Phosphoric diester hydrolase
Squamous Transitional Epithelial Cell Count
Buccal Surface
Cyclic AMP
Cystic Fibrosis
Cheek Structure
Calmodulin 1
Cyclic Adenosine Monophosphate Measurement

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