PMID: 11907166Mar 22, 2002Paper

Altered cardiovascular responses in mice lacking the M(1) muscarinic acetylcholine receptor

The Journal of Pharmacology and Experimental Therapeutics
Sandrine N HardouinN M Nathanson

Abstract

Although the M(2) muscarinic acetylcholine receptor (mAChR) is the predominant functional mAChR subtype in the heart, some responses of the cardiovascular system to acetylcholine (ACh) may be mediated by other mAChR subtypes. The potential effect of M(1) mAChR on heart function was investigated using M(1) knockout (M(1)-KO) mice. In vivo cardiodynamic analysis showed that basal values of heart rate (HR), developed left ventricular pressure (DLVP), left ventricular dP/dt(max) (LV dP/dt(max)), and mean blood pressure (MBP) were similar between wild-type (WT) and M(1)-KO mice. Injection of the putative M(1)-selective agonist 4-(m-chlorophenyl-carbamoyloxy)-2-butynyltrimethylammonium (McN-A-343) produced an increase in LV dP/dt(max), DLVP, HR, and MBP in WT mice but did not affect hemodynamic function in the M(1)-KO mice. The stimulatory effect of McN-A-343 in WT mice was blocked by pretreatment with propranolol, indicating that stimulation of the M(1) mAChRs on sympathetic postganglionic neurons evoked release of catecholamines. Intravenous injection of ACh in both WT and M(1)-KO mice caused atrioventricular conduction block, without a significant change in the frequency of atrial depolarization, or atrial fibrillation. Immunoprec...Continue Reading

References

Sep 1, 1975·British Journal of Pharmacology·W Feniuk, B J Large
Jun 12, 1992·Annals of the New York Academy of Sciences·K M Kendrick, E B Keverne
Feb 1, 1992·Circulation·J W FlemingA M Watanabe
Jan 1, 1987·Annual Review of Neuroscience·N M Nathanson
Apr 1, 1989·Trends in Neurosciences·T I Bonner
Jun 1, 1993·Pharmacology & Therapeutics·M P Caulfield
Jan 1, 1993·Progress in Brain Research·M R BrannS V Jones
Dec 16, 1997·Proceedings of the National Academy of Sciences of the United States of America·S E HamiltonN M Nathanson
Nov 13, 1998·Proceedings of the National Academy of Sciences of the United States of America·U MendeE J Neer
Apr 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·C H RedfernB R Conklin
Jun 23, 2001·Journal of the American College of Cardiology·P KovoorD E Clapham

❮ Previous
Next ❯

Citations

Sep 24, 2005·Archives of Pharmacal Research·Sun-Hee WooChin Ok Lee
Apr 30, 2008·Naunyn-Schmiedeberg's Archives of Pharmacology·Jaromir MyslivecekJan Ricny
Dec 10, 2009·The Journal of Pharmacology and Experimental Therapeutics·Morgane ThomsenS Barak Caine
Jan 28, 2004·Annual Review of Pharmacology and Toxicology·Jürgen Wess
Jan 15, 2015·Stress : the International Journal on the Biology of Stress·Hana TomankovaJaromir Myslivecek
Jul 17, 2012·Neuropharmacology·Elise Demeter, Martin Sarter
Mar 1, 2012·Pharmacology, Biochemistry, and Behavior·Kodeeswaran ParameshwaranCarl A Pinkert
Oct 10, 2007·BJU International·Karl-Erik Andersson, Brian Olshansky
Feb 24, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·John T FisherJürgen Wess
Sep 4, 2010·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Priscilla D NegraesHenning Ulrich
Feb 6, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Ying FuRichard R Neubig
Nov 3, 2017·Physiological Genomics·Hannah C SaternosWissam A AbouAlaiwi
May 21, 2011·British Journal of Clinical Pharmacology·Karl-Erik AnderssonBrian Olshansky
Mar 27, 2021·American Journal of Physiology. Heart and Circulatory Physiology·Katarina TargosovaAnna Hrabovska
Aug 19, 2021·Arquivos brasileiros de cardiologia·Ítalo Martins de OliveiraPaulo Sampaio Gutierrez

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.