Altered CD45 expression in C77G carriers influences immune function and outcome of hepatitis C infection

Journal of Medical Genetics
Ritu DawesElma Tchilian

Abstract

A polymorphism in exon 4 (C77G) of CD45 that alters CD45 splicing has been associated with autoimmune and infectious diseases in humans. To investigate the effect of C77G in hepatitis C virus (HCV) infected individuals and study the phenotype and function of peripheral blood mononuclear cells (PBMC) from healthy and hepatitis C infected C77G carriers. C77G individuals showed an increased proportion of primed CD45RA and effector memory CD8 T cells and more rapid activation of the lymphocyte specific protein tyrosine kinase (Lck) following CD3 stimulation. Transgenic mice with CD45 expression mimicking that in human C77G variants had more activated/memory T cells, more rapid proliferative responses, and activation of Lck. Changes in CD45 isoform expression can alter immune function in human C77G variants and CD45 transgenic mice. The C77G allele may influence the outcome of HCV infection.

References

Jul 1, 1995·European Journal of Immunology·H ThudeR Schwinzer
Apr 17, 2001·Gut·A H Mohsen, UNKNOWN Trent HCV Study Group
Apr 18, 2001·The Journal of Biological Chemistry·K W Lynch, A Weiss
Apr 27, 2001·Nature Immunology·J M PenningerA J Oliveira-dos-Santos
Nov 5, 2002·Annual Review of Immunology·Michelle L HermistonArthur Weiss
Apr 30, 2003·Proceedings of the National Academy of Sciences of the United States of America·Tara StantonElma Z Tchilian
Mar 31, 2004·Experimental Gerontology·Qin OuyangGraham Pawelec
Aug 11, 2004·International Immunology·Elma Z TchilianPeter C L Beverley
Aug 31, 2004·Human Molecular Genetics·Sally BoxallElma Z Tchilian

❮ Previous
Next ❯

Citations

Aug 1, 2007·Molecular and Cellular Biology·Alexis A MeltonKristen W Lynch
Nov 15, 2006·Clinical and Experimental Immunology·E Z TchilianP C L Beverley
May 28, 2013·Biochimica Et Biophysica Acta·Wiljan J A J Hendriks, Rafael Pulido
Sep 11, 2009·PLoS Neglected Tropical Diseases·Jacqueline Araújo FiuzaRodrigo Correa-Oliveira
May 24, 2017·Molecular BioSystems·Kasi Viswanatharaju Ruddraraju, Zhong-Yin Zhang
Sep 1, 2009·Viruses·Bertram BengschHubert E Blum
May 28, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Zuopeng WuChristopher C Goodnow
Dec 6, 2020·Proceedings of the National Academy of Sciences of the United States of America·Víctor BordaHeinner Guio

❮ Previous
Next ❯

Related Concepts

Related Feeds