Altered center-surround motion inhibition in schizophrenia.

Biological Psychiatry
Yue ChenDost Ongur

Abstract

Schizophrenia is a brain disorder that spans across biological and behavioral levels. The links between altered neural circuitry and abnormal behaviors are yet to be understood. Visual motion perception has been established in basic neuroscience and may provide an opportunity to link different levels of brain functions in schizophrenia. Center-surround interaction is a ubiquitous neural mechanism underlying the organization of visual information over different spatial locations. We applied a psychophysical paradigm to examine center-surround interaction in schizophrenia. Patients (n = 24) and control subjects (n = 33) judged the direction of a moving random dot pattern (RDP, center) with and without the presence of another concentric surrounding RDP (surround). The presence of a moving surround shifted the perceptual judgments of center motion in the opposite direction from the surround in both subject groups but the magnitude of the perceptual shift was significantly larger in patients. The increased perceptual shift was not correlated with psychotic symptoms, which were mild in this patient sample, or antipsychotic medication. The increased perceptual shift suggests that the putative surround suppression on visual motion perc...Continue Reading

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Citations

Jul 22, 2009·Schizophrenia Bulletin·Jong H YoonCameron S Carter
Nov 22, 2008·Schizophrenia Bulletin·Michael F GreenVance Zemon
Aug 30, 2011·Brain and Cognition·Daniel J NortonYue Chen
Jul 12, 2011·Schizophrenia Research·Ava ElahipanahEyal M Reingold
Aug 19, 2008·Schizophrenia Research·Y ChenR McBain
Sep 14, 2015·Schizophrenia Research·Ivy F TsoStephan F Taylor
Jun 14, 2008·Biological Psychiatry·Pamela D ButlerSteven C Dakin
Apr 26, 2016·Psychiatry Research·Daniel J NortonYue Chen
Feb 28, 2015·Neuroscience and Biobehavioral Reviews·W A PhillipsS M Silverstein
May 10, 2011·Journal of Psychiatric Research·Kristopher I MathisMichael F Green
Aug 28, 2014·Frontiers in Integrative Neuroscience·Charles-Edouard NotredameRenaud Jardri
Dec 30, 2014·Frontiers in Psychology·Ignacio Serrano-PedrazaRoberto Rodriguez-Jimenez
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Jan 22, 2019·Royal Society Open Science·Colin J PalmerKiley J Seymour

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