Altered Circadian Rhythms and Breast Cancer: From the Human to the Molecular Level

Frontiers in Endocrinology
Hui-Hsien Lin, Michelle E Farkas

Abstract

Circadian clocks are fundamental, time-tracking systems that allow organisms to adapt to the appropriate time of day and drive many physiological and cellular processes. Altered circadian rhythms can result from night-shift work, chronic jet lag, exposure to bright lights at night, or other conditioning, and have been shown to lead to increased likelihood of cancer, metabolic and cardiovascular diseases, and immune dysregulation. In cases of cancer, worse patient prognoses and drug resistance during treatment have also been observed. Breast, colon, prostate, lung, and ovarian cancers and hepatocellular carcinoma have all been linked in one way or another with altered circadian rhythms. Critical elements at the molecular level of the circadian system have been associated with cancer, but there have been fairly few studies in this regard. In this mini-review, we specifically focus on the role of altered circadian rhythms in breast cancer, providing an overview of studies performed at the epidemiological level through assessments made in animal and cellular models of the disease. We also address the disparities present among studies that take into account the rhythmicity of core clock and other proteins, and those which do not, an...Continue Reading

References

Oct 1, 1969·The British Journal of Surgery·T Hamilton
Dec 12, 1980·Science·A J LewyS P Markey
Sep 9, 1995·BMJ : British Medical Journal·E PukkalaG Wahlberg
Sep 15, 1998·Biochemical and Biophysical Research Communications·S HonmaM Nomura
Aug 4, 1999·Proceedings of the National Academy of Sciences of the United States of America·C M PerouD Botstein
Sep 2, 1999·British Journal of Cancer·P D PharoahC Caldas
Aug 30, 2000·Nature·C M PerouD Botstein
Feb 22, 2001·Annual Review of Physiology·S M Reppert, D R Weaver
Jun 22, 2002·The Cochrane Database of Systematic Reviews·A Herxheimer, K J Petrie
Jun 5, 2003·Journal of the National Cancer Institute·Eva S SchernhammerGraham A Colditz
Jun 11, 1965·Science·J ASCHOFF
Feb 14, 2004·Proceedings of the National Academy of Sciences of the United States of America·Seung-Hee YooJoseph S Takahashi
Mar 26, 2005·Carcinogenesis·Shou-Tung ChenJan-Gowth Chang
Jun 18, 2005·Occupational and Environmental Medicine·K KojoA Auvinen
Aug 4, 2005·Journal of Biological Rhythms·Josephine Arendt
Nov 2, 2005·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Richard P MetzWeston W Porter
Nov 4, 2005·Journal of Biological Rhythms·Fabienne GuillaumondNicolas Cermakian
May 10, 2006·Molecular Carcinogenesis·Mu-Chin ShihJan-Gowth Chang
Jul 11, 2006·Cancer Science·Hui HuaFranz Halberg
Oct 17, 2006·PLoS Computational Biology·Mariko IzumoCarl Hirschie Johnson
Nov 3, 2007·Cancer Research·Akila N ViswanathanEva S Schernhammer
Mar 13, 2008·Journal of Circadian Rhythms·Shulin XiangSteven M Hill
Apr 30, 2008·Molecular Carcinogenesis·Yueh-Min LinJan-Gowth Chang
Jul 25, 2008·Breast Cancer Research and Treatment·Xiaoming YangWilliam J M Hrushesky
Aug 13, 2008·International Journal of Cancer. Journal International Du Cancer·Tuuli A LahtiEero Pukkala
Aug 23, 2008·Acta Obstetricia Et Gynecologica Scandinavica·Hideki TokunagaNobuo Yaegashi
Aug 30, 2008·American Journal of Physiology. Endocrinology and Metabolism·Takahiro J NakamuraGene D Block
Nov 20, 2008·Physiological Genomics·Patricia D ManingatMorey W Haymond
Jun 3, 2009·Proceedings of the National Academy of Sciences of the United States of America·Yoichi MinamiHiroki R Ueda
Dec 10, 2009·The Lancet Oncology·Robert BaanUNKNOWN WHO International Agency for Research on Cancer Monograph Working Group

❮ Previous
Next ❯

Citations

Jul 31, 2019·Cell Cycle·Sujeewa S Lellupitiyage DonMichelle E Farkas
Jun 20, 2020·International Journal of Clinical Practice·Hélida C Aquino-SantosRodolfo P Vieira
Oct 24, 2019·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Neil E CaporasoBarry I Graubard
Feb 8, 2021·Drug Discovery Today·Matteo Astone, Massimo M Santoro
Mar 31, 2021·Drug Discovery Today·Rodrigo F N RibeiroMaria Manuel C Silva
May 8, 2021·Neuro-oncology Advances·Anna R DamatoJian L Campian
Jul 3, 2021·International Journal of Environmental Research and Public Health·Deborah J BowenMarion Kavanaugh-Lynch

❮ Previous
Next ❯

Methods Mentioned

BETA
methylation profiling
confocal microscopy

Related Concepts

Related Feeds

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.

Breast Cancer: Chemo-Resistance

Some cancers are difficult to treat and aggressive including the "triple-negative" breast cancer. This type of cancer is chemoresistant even before chemotherapy begins. Here are the latest discoveries chemo-resistance in breast cancer.

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.

Related Papers

Cold Spring Harbor Symposia on Quantitative Biology
L J PtácekY-H Fu
Revista española de geriatría y gerontología
Elisabet Ortiz-TudelaPilar Mendiola
International Journal of Molecular Sciences
Daniel Gutierrez, Joshua Arbesman
Current Opinion in Cell Biology
Yasukazu NakahataPaolo Sassone-Corsi
© 2022 Meta ULC. All rights reserved