Altered colonic sensory and barrier functions by CRF: roles of TLR4 and IL-1

The Journal of Endocrinology
Tsukasa NozuToshikatsu Okumura

Abstract

Visceral allodynia and increased colonic permeability are considered to be crucial pathophysiology of irritable bowel syndrome (IBS). Corticotropin-releasing factor (CRF) and immune-mediated mechanisms have been proposed to contribute to these changes in IBS, but the precise roles have not been determined. We explored these issues in rats in vivo. The threshold of visceromotor response, i.e., abdominal muscle contractions induced by colonic balloon distention was electrophysiologically measured. Colonic permeability was estimated by quantifying the absorbed Evans blue in colonic tissue. Intraperitoneal injection of CRF increased the permeability, which was blocked by astressin, a non-selective CRF receptor antagonist, but astressin2-B, a selective CRF receptor subtype 2 (CRF2) antagonist did not modify it. Urocortin 2, a selective CRF2 agonist inhibited the increased permeability by CRF. Eritoran, a toll-like receptor 4 (TLR4) antagonist or anakinra, an interleukin-1 receptor antagonist blocked the visceral allodynia and the increased gut permeability induced by CRF. Subcutaneous injection of lipopolysaccharide (immune stress) or repeated water avoidance stress (WAS, psychological stress), 1 h daily for 3 days induced visceral ...Continue Reading

References

Feb 28, 2001·Proceedings of the National Academy of Sciences of the United States of America·T M ReyesP E Sawchenko
Jun 21, 2001·Proceedings of the National Academy of Sciences of the United States of America·K LewisW W Vale
Oct 11, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Otilia ObrejaMichaela Kress
Jan 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christos TsatsanisAndrew N Margioris
Apr 14, 2006·Alimentary Pharmacology & Therapeutics·G M MaweP L Moses
Jan 24, 2007·Gastroenterology·Giovanni BarbaraRoberto Corinaldesi
Mar 27, 2007·Gastroenterology·Tobias LiebregtsGerald Holtmann
May 19, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·Mélanie G GareauMary H Perdue
Jul 19, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Aaron A TeitelbaumMary H Perdue
Aug 12, 2008·Psychoneuroendocrinology·Javier SantosMary H Perdue
Nov 21, 2008·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·M KiddI M Modlin
May 2, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Muriel LaraucheYvette Taché
Jul 21, 2009·Current Gastroenterology Reports·Yvette TachéAndreas Stengel
Oct 8, 2009·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·D o'malleyJ F Cryan
Apr 22, 2010·The American Journal of Gastroenterology·Paul ScullyEamonn M M Quigley
Apr 2, 2011·Journal of Gastroenterology and Hepatology·Motoyori KanazawaShin Fukudo
May 18, 2011·Experimental Neurology·Muriel LaraucheYvette Taché
Jul 21, 2011·The Journal of Biological Chemistry·Takuya SuzukiSoichi Tanabe
Apr 21, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Pu-Qing YuanYvette Taché
Sep 14, 2012·Journal of Clinical Gastroenterology·Giovanni BarbaraVincenzo Stanghellini
Dec 5, 2012·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·T NozuT Okumura
Feb 20, 2014·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·T Piche
Jun 20, 2014·World Journal of Gastroenterology : WJG·Mylene Nébot-VivinusVassilia Theodorou
May 13, 2015·Journal of Gastroenterology·Tsukasa Nozu, Toshikatsu Okumura
Sep 22, 2015·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·A DlugoszG Lindberg
Jan 9, 2016·American Journal of Physiology. Gastrointestinal and Liver Physiology·Pu-Qing YuanYvette Taché
May 5, 2016·Gastroenterology·Fermín MearinRobin Spiller
Nov 28, 2017·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Hu YueWang Xi

❮ Previous
Next ❯

Citations

Feb 12, 2019·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Yong LiWeimin Li
Feb 15, 2020·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Tsukasa NozuToshikatsu Okumura
Mar 11, 2020·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Yaping JiRichard J Traub
Apr 22, 2020·Therapeutic Advances in Gastroenterology·Maite Casado-Bedmar, Åsa V Keita
Jan 1, 2021·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Hanliang SunZhaojin Wang
Nov 5, 2019·Neuroscience Letters·Toshikatsu OkumuraMasumi Ohhira
May 7, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Tsukasa NozuToshikatsu Okumura
Jun 13, 2021·Journal of Pharmacological Sciences·Toshikatsu OkumuraMasumi Ohhira
Sep 19, 2020·European Journal of Pharmacology·Tsukasa NozuToshikatsu Okumura

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.