Altered contractility of circular and longitudinal muscle in TNBS-inflamed guinea pig ileum

The American Journal of Physiology
J P MartinolleL Buéno

Abstract

Intestinal motility disorders are often associated with gut inflammation. We evaluated, in vitro under isometric conditions, changes in contractility of longitudinal and circular muscle layers from guinea pig ileum after 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced ileitis. TNBS treatment did not modify length-active tension relationships for both muscle layers, whereas a significant increase in passive tension was observed in the circular muscle response to stretching. Moreover, in both control and inflamed strips at optimal stretch, concentration-response curves to KCl were similar for both layers. In contrast, contractile responses to receptor agonists were differentially altered in both layers in comparison with controls. Thus, in longitudinal strips from TNBS-treated ileum, there was a twofold increase in maximal response (Emax) induced by carbachol and histamine without modification of 50% effective concentration (EC50) values; responses to 5-hydroxytryptamine (5-HT) were not modified; both alpha 1- and alpha 2-adrenoceptor-mediated responses to epinephrine were abolished. In circular strips, inflammation did not affect the Emax induced by carbachol and histamine but led to increased EC50 values; Emax to 5-HT was red...Continue Reading

Citations

Mar 21, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Kazuya KinoshitaHideaki Karaki
Apr 14, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·Hirotada AkihoStephen M Collins
Jul 3, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·Jennifer R O'HaraKeith A Sharkey
Sep 6, 2002·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·A KellesJ Tack
Nov 25, 2016·American Journal of Physiology. Gastrointestinal and Liver Physiology·Ainsley M RobinsonKulmira Nurgali

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