Altered Cortical GABA in Female Veterans with Suicidal Behavior: Sex Differences and Clinical Correlates

Chronic Stress
Andrew PrescotDeborah Yurgelun-Todd

Abstract

Suicide is a public health concern in the civilian and veteran populations. Stressful life events are precipitating factors for suicide. The neurochemical underpinnings of the association between stress/trauma and suicide risk are unclear, especially in regards to sex differences. We hypothesized that gamma-amino butyric acid (GABA), the major inhibitory neurotransmitter may be a neurochemical candidate that is critical in the association between stress and suicide risk in veterans. Proton magnetic resonance spectroscopy (1H MRS) at 3.0 Tesla was used to measure in vivo neurochemistry in the anterior cingulate cortex (ACC; predominantly the dorsal ACC) of 81 veterans (16 females), including 57 (11 females) who endorsed past suicidal ideation (SI) and/or suicide attempt (SA) and 24 (5 females) with no history of SI and/or SA. Suicidal behavior (SB) was defined as the presence of SI and/or SA. We observed no significant differences in GABA/ Creatine+phosphocreatine (Cr+PCr) between veterans with SB (SB+) and without SB (SB-). However, the female SB+ group showed significantly reduced GABA/Cr+PCr vs. the female SB- group. We observed a trend-level significant negative correlation between GABA/Cr+PCr and the defensive avoidance (DA...Continue Reading

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Citations

Mar 28, 2019·Frontiers in Cellular Neuroscience·Manoela V Fogaça, Ronald S Duman

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Software Mentioned

Automated Segmentation Tool ( FAST )
FMRIB
Prior Knowledge Fitting (
ProFit
MATLAB
Brain Extraction Tools
Power
ProFit )
SPSS

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