Altered Cortico-Striatal Connectivity in Offspring of Schizophrenia Patients Relative to Offspring of Bipolar Patients and Controls

PloS One
Cristina Solé-PadullésGisela Sugranyes

Abstract

Schizophrenia (SZ) and bipolar disorder (BD) share clinical features, genetic risk factors and neuroimaging abnormalities. There is evidence of disrupted connectivity in resting state networks in patients with SZ and BD and their unaffected relatives. Resting state networks are known to undergo reorganization during youth coinciding with the period of increased incidence for both disorders. We therefore focused on characterizing resting state network connectivity in youth at familial risk for SZ or BD to identify alterations arising during this period. We measured resting-state functional connectivity in a sample of 106 youth, aged 7-19 years, comprising offspring of patients with SZ (N = 27), offspring of patients with BD (N = 39) and offspring of community control parents (N = 40). We used Independent Component Analysis to assess functional connectivity within the default mode, executive control, salience and basal ganglia networks and define their relationship to grey matter volume, clinical and cognitive measures. There was no difference in connectivity within any of the networks examined between offspring of patients with BD and offspring of community controls. In contrast, offspring of patients with SZ showed reduced conn...Continue Reading

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Citations

Nov 15, 2019·Bipolar Disorders·Kareen HeinzeHeather C Whalley
Apr 13, 2018·International Journal of Molecular Sciences·Ching-Ann LiuHorng-Jyh Harn
Dec 24, 2018·Schizophrenia Bulletin·Dinesh K ShuklaL Elliot Hong
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Methods Mentioned

BETA
PCA

Software Mentioned

SPM8
Statistical Package for Social Sciences ( SPSS
Statistical Parametric Mapping SPM8
Matlab
Group ICA
SPSS
Group ICA fMRI Toolbox ( GIFT
GIFT

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