Altered cytokeratin expression during chemoprevention of experimental hamster buccal pouch carcinogenesis by garlic

Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
S BalasenthilS Nagini

Abstract

Cytokeratins (also known as keratins (K)) are members of the family of intermediate filaments and form major components of the mammalian epithelial cell cytoskeleton. Cytokeratins have emerged as reliable cellular markers of oral cancer development and chemoprevention because of their abundance, stability and high antigenicity. We investigated the effect of aqueous garlic extract on cytokeratin expression during 7,12-dimethylbenz[a]anthracene (DMBA)-induced hamster buccal pouch (HBP) carcinogenesis. Hamsters were divided into four groups of six animals. Animals in group 1 were painted with a 0.5% solution of DMBA in liquid paraffin, on the right buccal pouches, three times a week for 14 weeks. Group 2 animals were painted with DMBA as in group 1 and also received 250 mg/kg body weight aqueous garlic extract orally on alternate days to the DMBA application. Group 3 animals received garlic extract only, as in group 2. Group 4 animals received neither DMBA nor garlic extract and served as the control. The hamsters were killed after an experimental period of 14 weeks. Cytokeratin expression was studied using human monoclonal antibodies AE1 and AE3, which react with type I and II keratins. In DMBA-induced squamous cell carcinomas, d...Continue Reading

References

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Nov 26, 1999·Cancer Detection and Prevention·S BalasenthilS Nagini
Jun 1, 2000·Asia Pacific Journal of Clinical Nutrition·S Balasenthil, S Nagini

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Citations

Nov 9, 2004·Clinica Chimica Acta; International Journal of Clinical Chemistry·V BhuvaneswariS Nagini
Sep 16, 2003·International Journal of Hygiene and Environmental Health·Salama A Salama, William W Au
Jan 15, 2008·Biochemical and Biophysical Research Communications·Leslie A GapterKa-Yun Ng

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