PMID: 15345199Sep 4, 2004Paper

Altered cytokine production in mice exposed to lead acetate

International Journal of Immunopathology and Pharmacology
I IavicoliG Carelli

Abstract

Previous investigations have shown that Pb exerts immunotoxic effects. Object of this study were Th1 and Th2-type immune responses of mice to Pb exposure. Adult Swiss male mice were administered 0, 40 and 400 mg/l of Pb (as acetate) in drinking water for 14 days. At the end of the treatment, blood Pb was determined and two Th1 cytokines (IL-2, INF-gamma) and one Th2 serum cytokine (IL-4) were measured. A significant increase in IL-4 production was observed in the mice exposed to 40 mg/l of Pb, while a further increase in IL-4 production was associated with a decrease in INF-gamma production in mice exposed to 400 mg/l of Pb. On the other hand, Pb exposure did not induce changes of serum IL-2 (involved also in the Th0 immune pattern). Our findings indicate that low level Pb exposure enhances a Th2 response. A high Pb does can either stimulate the Th2 immune activity or reduce the Th1 response; the result is an imbalance between Th1 and Th2 activation.

References

Aug 1, 1991·Immunology Today·S Romagnani
Oct 1, 1991·Immunological Reviews·R L CoffmanR Chatelain
Oct 11, 1991·Toxicology and Applied Pharmacology·M J McCabe, D A Lawrence
Jul 1, 1991·Archives of Environmental Contamination and Toxicology·P T RedigG E Duke
Jul 1, 1991·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·M KowolenkoD Lawrence
Dec 1, 1987·The Journal of Experimental Medicine·E A Kurt-JonesA K Abbas
Jan 1, 1988·International Journal of Immunopharmacology·G L Warner, D A Lawrence
May 1, 1996·Toxicology and Applied Pharmacology·Y HeoD A Lawrence
Dec 2, 1998·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·J E LeighP L Fidel
May 18, 2000·Biochemical Society Transactions·M P PiccinniS Romagnani
Mar 7, 2002·Toxicology Letters·I IavicoliE J Calabrese

❮ Previous
Next ❯

Citations

Sep 4, 2012·Dose-response : a Publication of International Hormesis Society·Ivo IavicoliAlessandro Alimonti
Jan 6, 2018·Biological Trace Element Research·Yachao WangXuegang Luo
Dec 26, 2015·International Journal of Environmental Research and Public Health·Clement G YedjouPaul B Tchounwou
Mar 4, 2020·Environmental Toxicology and Chemistry·Biyao HanNico W van den Brink

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved