PMID: 11912528Mar 26, 2002Paper

Altered distribution of Sertoli cell vimentin and increased apoptosis in cryptorchid rats

Journal of Pediatric Surgery
Zhong Qiu WangToshifumi Itano

Abstract

Sertoli cell cytoskeletons play an important role in the process of spermatogenesis. The authors investigated the effects of cryptorchidism in immature rats on the distribution of Sertoli cell cytoskeletons and the incidence of testis germ cell apoptosis. Immature 3-week-old rats were made cryptorchid unilaterally, and the distribution of Sertoli cell cytoskeletons by immunohistochemistry and germ cell apoptosis by TUNEL technique were evaluated at different day intervals. Immunohistochemical staining from control rats showed that the distribution of vimentin in Sertoli cells changes in developing rats. Basally, it is localized in the perinuclear region of the cell as well as in filament networks that project into the apical Sertoli cell cytoplasm in a "spokelike" pattern. In cryptorchidism, there was an intense vimentin immunoreactivity surrounding Sertoli cell nuclei along with the collapse of the apical extensions. This became significantly evident by 7 days. Microtubules occur in Sertoli cell cytoplasm apical to the nucleus. Cryptorchidism did not alter their distribution. Spontaneous apoptosis of germ cells occurs in the control testis, and a markedly increased incidence of apoptosis was observed in cryptorchidism by 7 day...Continue Reading

Citations

Oct 1, 2005·Pathology Oncology Research : POR·Mehmet DündarHaluk Erol
Oct 18, 2011·Archives of Environmental Contamination and Toxicology·Pinar ErkekogluFiliz Hincal
May 17, 2008·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Taiza StumppSandra M Miraglia
Feb 6, 2010·The Journal of Reproduction and Development·Bhuminand DevkotaYoh-Ichi Miyake
May 20, 2011·Equine Veterinary Journal·M LydkaB Bilińska
Sep 20, 2016·Oxidative Medicine and Cellular Longevity·Chen YaoBingyi Shi
Nov 19, 2005·The Journal of Reproduction and Development·Bhuminand DevkotaYoh-Ichi Miyake
Jul 24, 2004·International Journal of Andrology·Zhi-Hong ZhangYi-Xun Liu
May 5, 2021·Theriogenology·Pengfei ZhangMing Zhang
Aug 27, 2005·Developmental Biology·Rosa M BaleatoShaun D Roman

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