PMID: 8960315Dec 1, 1996Paper

Altered distribution of the alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor subunit GluR2(4) and the N-methyl-D-aspartate receptor subunit NMDAR1 in the hippocampus of patients with temporal lobe epilepsy

Acta Neuropathologica
I BlümckeO D Wiestler

Abstract

In patients with therapy-refractory temporal lobe epilepsy (TLE), alterations of glutamate receptors have been proposed as a mechanism for enhanced excitability. Using commercially available monoclonal antibodies specific for the N-methyl-D-aspartate (NMDA) receptor subunit NMDAR1 and for the alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor subunit GluR2(4), we have examined the distribution of these polypeptides in human hippocampal tissue that was surgically removed from patients with intractable TLE. Surgical specimens were classified according to the presence of Ammon's horn sclerosis (AHS) or a focal lesion in the temporal lobe. Cell counts and a densitometric analysis of the immunoreactivity patterns were carried out for all hippocampal subfields. NMDAR1 and GluR2(4) levels were markedly reduced in patients with AHS, primarily in those subfields with substantial neuronal cell loss (in particular CA1, CA4 and CA3), compared to those seen in patients with focal lesions and in control specimens obtained at autopsy. In contrast, the molecular layer of the dentate gyrus (DG-ML) showed significantly higher levels of GluR2(4) immunoreactivity in AHS compared to control tissue, while NMDAR1 showed no significant up-...Continue Reading

Citations

Oct 7, 1998·Epilepsy Research·H XieN C de Lanerolle
Oct 9, 1999·Epilepsy Research·B S MeldrumA G Chapman
Oct 9, 1999·Epilepsy Research·I BlümckeO D Wiestler
Jun 6, 2003·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Michael V Johnston
Apr 13, 2000·The European Journal of Neuroscience·A SíkT F Freund
Sep 22, 2000·Epilepsia·I BlümckeO D Wiestler
Apr 17, 2002·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Helen E Scharfman
Oct 16, 1999·Proceedings of the National Academy of Sciences of the United States of America·T GrunwaldC E Elger
Jan 7, 2014·Expert Opinion on Therapeutic Targets·Rita CitraroEmilio Russo
Nov 22, 2000·Experimental Neurology·M D IkonomovicD M Armstrong
Jan 9, 2013·Arquivos de neuro-psiquiatria·Luís Otávio Sales Ferreira CabocloAmérico Ceiki Sakamoto
Oct 26, 1999·The Journal of Comparative Neurology·I BlümckeO D Wiestler
Aug 8, 2006·Medicinal Research Reviews·Daniela CatarziFlavia Varano
Nov 26, 2009·Annals of Neurology·Joel S F GreenwoodScott C Baraban
Jul 2, 2011·Life Sciences·Gianina Teribele VenturinJaderson Costa DaCosta

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