Altered distribution of the gangliosides GM1 and GM2 in Alzheimer's disease

Dementia and Geriatric Cognitive Disorders
Z PernberM Blomqvist

Abstract

Alzheimer's disease (AD) is a neurodegenerative disorder where β-amyloid tends to aggregate and form plaques. Lipid raft-associated ganglioside GM1 has been suggested to facilitate β-amyloid aggregation; furthermore, GM1 and GM2 are increased in lipid rafts isolated from cerebral cortex of AD cases. The distribution of GM1 and GM2 was studied by immunohistochemistry in the frontal and temporal cortex of AD cases. Frontotemporal dementia (FTD) was included as a contrast group. The distribution of GM1 and GM2 changes during the process of AD (n = 5) and FTD (n = 3) compared to controls (n = 5). Altered location of the GM1-positive small circular structures seems to be associated with myelin degradation. In the grey matter, the staining of GM1-positive plasma membranes might reflect neuronal loss in the AD/FTD tissue. The GM1-positive compact bundles were only visible in cells located in the AD frontal grey matter, possibly reflecting raft formation of GM1 and thus a pathological connection. Furthermore, our results suggest GM2 to be enriched within vesicles of pyramidal neurons of the AD/FTD brain. Our study supports the biochemical finding of ganglioside accumulation in cellular membranes of AD patients and shows a redistributio...Continue Reading

References

Apr 1, 1991·Neuron·D J Selkoe
Apr 17, 1990·Biochimica Et Biophysica Acta·G KarlssonL Svennerholm
Jan 1, 1991·Acta Neuropathologica·H Braak, E Braak
Oct 1, 1991·Archives of Neurology·K BlennowL Svennerholm
Jan 1, 1990·Molecular Neurobiology·K S Kosik
Apr 1, 1988·The Biochemical Journal·P FredmanL Svennerholm
Sep 25, 1989·Biochimica Et Biophysica Acta·L SvennerholmB M Rynmark
Jun 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·C L MastersK Beyreuther
Jan 1, 1980·Advances in Experimental Medicine and Biology·R W LedeenJ E Haley
Jan 1, 1994·Annual Review of Neuroscience·D J Selkoe
Jun 5, 1997·Nature·K Simons, E Ikonen
Mar 21, 1998·The Journal of Biological Chemistry·J McLaurinA Chakrabartty
Jun 12, 1998·Nature Medicine·S J LeeK S Kosik
Jul 15, 1998·The Journal of Membrane Biology·D A Brown, E London
Aug 6, 1999·Brain Research·W Cammer, H Zhang
May 23, 2001·Archives of Biochemistry and Biophysics·T ArigaT Miyatake
Jun 2, 2001·Journal of Neurocytology·E S AndersonC Hildebrand
Feb 2, 2002·The British Journal of Psychiatry : the Journal of Mental Science·Julie S SnowdenDavid M A Mann
Feb 19, 2002·Neurobiology of Disease·Suzanne WahrleTodd E Golde
Jan 8, 2003·The Journal of Cell Biology·Robert EhehaltKai Simons
Sep 23, 2003·Journal of Neurocytology·Alan Peters
Sep 25, 2003·Proceedings of the National Academy of Sciences of the United States of America·Joanna M CordyAnthony J Turner
Mar 31, 2004·Molecular Psychiatry·Q ZhaD Zhang
Jun 19, 2004·Molecular Membrane Biology·Alex J Laude, Ian A Prior
Aug 24, 2004·The Journal of Biological Chemistry·Kulandaivelu S VetrivelGopal Thinakaran
Oct 7, 2004·Biochimica Et Biophysica Acta·Steven U Walkley, Kinuko Suzuki

❮ Previous
Next ❯

Citations

Feb 28, 2014·BioMed Research International·Marcus O W GrimmTobias Hartmann
Mar 26, 2013·FEBS Letters·Martino Calamai, Francesco S Pavone
Dec 12, 2012·IUBMB Life·Ibolya E András, Michal Toborek
Jun 7, 2014·Journal of Neuroscience Research·Toshio Ariga
Nov 9, 2016·The Journal of Nutritional Biochemistry·Mounir BelkouchNathalie Bernoud-Hubac
May 6, 2015·Trends in Biochemical Sciences·Cara-Lynne Schengrund
Aug 16, 2016·Ageing Research Reviews·Emyr Lloyd-Evans, Luke J Haslett
Oct 30, 2016·Biochimie·Julie ColinThierry Oster
Sep 19, 2016·Acta Neuropathologica Communications·Silke HerzerViola Nordström
Sep 7, 2012·Chemical Society Reviews·Maria A Telpoukhovskaia, Chris Orvig
Nov 6, 2014·Biomolecular Concepts·Blaine BiselMartino Calamai
Sep 19, 2017·Journal of Alzheimer's Disease : JAD·Roberta CascellaCristina Cecchi
Sep 13, 2020·Membranes·Vladimir Rudajev, Jiri Novotny
Apr 11, 2020·International Journal of Molecular Sciences·Bernadette Breiden, Konrad Sandhoff
Jun 17, 2020·FEBS Letters·Woo-Jae Park, Joo-Won Park
Oct 14, 2020·Journal of Neurochemistry·Martina Blank, Carsten Hopf
Jun 11, 2021·Expert Opinion on Therapeutic Targets·Mani Iyer PrasanthJames Michael Brimson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alzheimer's Disease: APP

Amyloid precursor protein (APP) proteolysis is critical for the development of Alzheimer's disease, a neurodegenerative disease associated with accumulation of amyloid plaques in the brain. Here is the latest research on APP and Alzheimer's disease.

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.

Astrocytes & Amyloid

Astrocytes are thought to play a role in amyloid production and have been implicated in neurodegenerative diseases such as Alzheimer’s disease. Here is the latest research on the relationship between astrocytes and amyloid.

Attention Disorders

Attention is involved in all cognitive activities, and attention disorders are reported in patients with various neurological diseases. Here are the latest discoveries pertaining to attention disorders.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Astrocytes & Neurodegeneration

Astrocytes are important for the health and function of the central nervous system. When these cells stop functioning properly, either through gain of function or loss of homeostatic controls, neurodegenerative diseases can occur. Here is the latest research on astrocytes and neurodegeneration.