Altered distributions of bone tissue mineral and collagen properties in women with fragility fractures

Bone
Zhen Xiang WangEve Donnelly

Abstract

Heterogeneity of bone tissue properties is emerging as a potential indicator of altered bone quality in pathologic tissue. The objective of this study was to compare the distributions of tissue properties in women with and without histories of fragility fractures using Fourier transform infrared (FTIR) imaging. We extended a prior study that examined the relationship of the mean FTIR properties to fracture risk by analyzing in detail the widths and the tails of the distributions of FTIR properties in biopsies from fracture and non-fracture cohorts. The mineral and matrix properties of cortical and trabecular iliac crest tissue were compared in biopsies from women with a history of fragility fracture (+Fx; n=21, age: mean 54±SD 15y) and with no history of fragility fracture (-Fx; n=12, age: 57±5y). A subset of the patients included in the -Fx group were taking estrogen-plus-progestin hormone replacement therapy (HRT) (-Fx+HRT n=8, age: 58±5y) and were analyzed separately from patients with no history of HRT (-Fx-HRT n=4, age: 56±7y). When the FTIR parameter mean values were examined by treatment group, the trabecular tissue of -Fx-HRT patients had a lower mineral:matrix ratio (M:M) and collagen maturity (XLR) than that of -Fx+HR...Continue Reading

References

Jul 15, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·E F EriksenM Kassem
May 9, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·H Ou-YangR Mendelsohn
Oct 5, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·E P PaschalisM Yamauchi
Nov 22, 2001·Journal of Biomechanics·J C van der LindenH Weinans
Jun 11, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Catherine P TarnowskiMichael D Morris
Jun 24, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·E P PaschalisE F Eriksen
Sep 25, 2003·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·UNKNOWN John D. Currey
Oct 2, 2003·JAMA : the Journal of the American Medical Association·Jane A CauleyUNKNOWN Women's Health Initiative Investigators
Mar 30, 2004·Journal of Biomechanics·Benjamin C Bourne, Marjolein C H van der Meulen
Jul 3, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Ethel S SirisThomas A Abbott
Aug 10, 2005·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A L BoskeyRichard Mendelsohn
Oct 19, 2005·Journal of Biomedical Optics·Adele Boskey, Richard Mendelsohn
Mar 1, 1969·Journal of Biomechanics·J D Currey
May 23, 2007·Nature Materials·Kuangshin TaiChristine Ortiz
May 25, 2007·Current Osteoporosis Reports·Deepak Vashishth
Dec 22, 2007·Bone·P RoschgerK Klaushofer
Apr 1, 2008·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M SaitoK Marumo
Aug 30, 2008·Journal of Biomechanics·G A P RendersT M G J van Eijden
Feb 13, 2009·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Samuel Gourion-ArsiquaudAdele L Boskey
May 8, 2009·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Samuel Gourion-ArsiquaudAdele L Boskey
Oct 25, 2011·Nature Materials·Robert O Ritchie
Nov 11, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Eve DonnellyAdele L Boskey
Aug 7, 2012·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Samuel Gourion-ArsiquaudAdele L Boskey
Apr 5, 2014·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Eve DonnellyAdele L Boskey
Jun 28, 2014·Current Osteoporosis Reports·Philipp J Thurner, Orestis L Katsamenis

❮ Previous
Next ❯

Citations

Apr 14, 2016·International Journal of Endocrinology·Karina Bortolin LodiRosilene Fernandes da Rocha
Jun 6, 2016·Current Osteoporosis Reports·Jeffry S NymanGeorge M Pharr
Jul 31, 2018·Annals of the New York Academy of Sciences·James P KarchnerNancy Pleshko
Jan 27, 2018·Scientific Reports·Neashan MathavanHanna Isaksson
Feb 13, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·William QueridoNancy Pleshko

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
Eve DonnellyA L Boskey
Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
Samuel Gourion-ArsiquaudA L Boskey
Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
E P PaschalisErik F Eriksen
Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
Eve DonnellyA L Boskey
© 2022 Meta ULC. All rights reserved