PMID: 8953386Dec 1, 1996Paper

Altered drug translocation mediated by the MDR protein: direct, indirect, or both?

Journal of Bioenergetics and Biomembranes
Paul D RoepeF Fritz

Abstract

Overexpression of the MDR protein, or p-glycoprotein (p-GP), in cells leads to decreased initial rates of accumulation and altered intracellular retention of chemotherapeutic drugs and a variety of other compounds. Thus, increased expression of the protein is related to increased drug resistance. Since several homologues of the MDR protein (CRP, ItpGPA, PDR5, sapABCDF) are also involved in conferring drug resistance phenomena in microorganisms, elucidating the function of the MDR protein at a molecular level will have important general applications. Although MDR protein function has been studied for nearly 20 years, interpretation of most data is complicated by the drug-selection conditions used to create model MDR cell lines. Precisely what level of resistance to particular drugs is conferred by a given amount of MDR protein, as well as a variety of other critical issues, are not yet resolved. Data from a number of laboratories has been gathered in support of at least four different models for the MDR protein. One model is that the protein uses the energy released from ATP hydrolysis to directly translocate drugs out of cells in some fashion. Another is that MDR protein overexpression perturbs electrical membrane potential (de...Continue Reading

References

Jan 9, 1992·Biochemical Pharmacology·W T Beck, X D Qian
Jul 15, 1992·European Journal of Biochemistry·E C SpoelstraJ Lankelma
Jan 1, 1992·Trends in Biochemical Sciences·C F Higgins, M M Gottesman
Aug 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·P GrosF Talbot
Oct 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·A R Safa
May 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·M HorioI Pastan
Mar 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·B C GuildD E Housman
Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·M M CornwellI Pastan
Jan 1, 1986·Annual Review of Biochemistry·G F Ames
May 9, 1986·Biochimica Et Biophysica Acta·L D MayerP R Cullis
Aug 11, 1995·Science·M J StuttsR C Boucher
Jul 7, 1995·The Journal of Biological Chemistry·A B Shapiro, V Ling
Feb 1, 1995·Journal of Bioenergetics and Biomembranes·A B Shapiro, V Ling
Jan 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·E H AbrahamH F Cantiello
Dec 1, 1994·The Journal of General Physiology·G R EhringM D Cahalan
Dec 1, 1994·Trends in Pharmacological Sciences·P D Roepe
Dec 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·S RuetzP Gros
Dec 12, 1993·Biochimica Et Biophysica Acta·R M Wadkins, P J Houghton
Apr 15, 1994·Biochemical and Biophysical Research Communications·C E Bear
Apr 26, 1994·Proceedings of the National Academy of Sciences of the United States of America·S M Simon, M Schindler
Aug 1, 1994·The American Journal of Physiology·D B LuckieJ J Wine
Jul 1, 1994·Trends in Pharmacological Sciences·S Ruetz, P Gros
Jan 1, 1993·Annual Review of Biochemistry·M M Gottesman, I Pastan
Oct 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·G A AltenbergL Reuss
Feb 9, 1993·Biochemistry·G J TurnerR M Stroud

❮ Previous
Next ❯

Citations

May 7, 2005·Acta Tropica·Manoj T Duraisingh, Alan F Cowman
Apr 2, 1999·Trends in Pharmacological Sciences·P D Roepe, J A Martiney
Feb 21, 2002·Biochimica Et Biophysica Acta·Anna Maria PorcelliMichela Rugolo
Mar 24, 2011·The Cancer Journal·Valentina FodaleEmanuel Petricoin
May 1, 2013·Antimicrobial Agents and Chemotherapy·Catarina CostaMiguel C Teixeira
Mar 1, 2014·The Journal of Antimicrobial Chemotherapy·Catarina CostaMiguel C Teixeira
Jun 15, 2004·Biochemical Pharmacology·Anca Dragomir, Godfried M Roomans
May 21, 2013·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Julia FredeMustafa B A Djamgoz
Aug 2, 2001·The Journal of Pharmacy and Pharmacology·M CastaingM Dani
Apr 2, 2014·Frontiers in Physiology·Katy S Sherlach, Paul D Roepe
Sep 5, 2002·Medicinal Research Reviews·Lyann M B Ursos, Paul D Roepe
Aug 27, 2005·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Rangan Maitra, Joshua W Hamilton
Apr 10, 1999·The Journal of Biological Chemistry·J H WeisburgD A Scheinberg
Aug 1, 1997·FEMS Microbiology Reviews·H BolhuisW N Konings

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacterial Respiration

This feed focuses on cellular respiration in bacteria, known as bacterial respiration. Discover the latest research here.

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.