Altered Dynamics of the fMRI Response to Faces in Individuals with Autism

Journal of Autism and Developmental Disorders
Natalia M KleinhansElizabeth Aylward

Abstract

Abnormal fMRI habituation in autism spectrum disorders (ASDs) has been proposed as a critical component in social impairment. This study investigated habituation to fearful faces and houses in ASD and whether fMRI measures of brain activity discriminate between ASD and typically developing (TD) controls. Two identical fMRI runs presenting masked fearful faces, houses, and scrambled images were collected. We found significantly slower fMRI responses to fearful faces but not houses in ASD. In addition, the pattern of slow to emerge amygdala activation to faces had robust discriminability [ASD vs. TD; area under the curve (AUC) = .852, p < .001]. In contrast, habituation to houses had no predictive value (AUC = .573, p = .365). Amygdala habituation to emotional faces may be useful for quantifying risk in ASD.

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Citations

Nov 9, 2016·Behavioural Brain Research·Giovanni ProvenzanoYuri Bozzi
Sep 29, 2018·PloS One·Mackenzie A SundayIsabel Gauthier
Apr 13, 2020·Journal of Autism and Developmental Disorders·Marta Del Valle RubidoDaniel Umbricht
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Feb 27, 2021·Addiction Biology·Paul S RegierAnna Rose Childress
Mar 16, 2021·Developmental Neuropsychology·Caitlin M HudacSara Jane Webb
Mar 20, 2021·Journal of Autism and Developmental Disorders·Iti AroraMadeleine Groom
Mar 20, 2018·Brain and Cognition·Caitlin M HudacRaphael A Bernier

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