Altered effects of angiotensin ii type 1 and type 2 receptor blockers on cardiac norepinephrine release and inotropic responses during cardiac sympathetic nerve stimulation in aorto-caval shunt rats

Circulation Journal : Official Journal of the Japanese Circulation Society
Hitoshi SuzukiYukio Maruyama

Abstract

Inhibition of the sympathetic nervous and renin - angiotensin systems has become an important strategy in the treatment of chronic heart failure. However, direct evidence of how inhibition of the renin - angiotensin system alters sympathetic activity in a diseased heart is lacking. Four weeks after abdominal aorto-caval (AV) shunting or sham operation in rats, the hearts were retrogradely perfused in vivo and the left ventricles contracted isovolumetrically at 300 beats/min. Sympathetic nerve stimulation (SNS) was performed in the baseline state and repeated with an infusion of the angiotensin II (A-II) type 1 receptor (AT(1)-R) blocker, losartan, the A-II type 2 receptor (AT(2)-R) blocker, PD123319, or A-II. Norepinephrine (NE) overflow and left ventricular (LV) inotropic responses during baseline SNS were lower in the AV shunt rats. Losartan did not change the NE overflow or the LV inotropic responses to SNS in the sham rats, but did increase them in the AV shunt rats. PD123319 changed neither parameter in the sham rats, but decreased both in the AV shunt rats. A-II enhanced the NE overflow but attenuated the LV inotropic responses to SNS in the sham rats, but attenuated both in the AV shunt rats. The effects of A-II via the ...Continue Reading

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Citations

Sep 22, 2009·European Journal of Pharmacology·Tatsuhiko MoriYasuo Matsumura
Oct 21, 2015·Seminars in Immunopathology·Tomohiro NumataRyuji Inoue
Dec 6, 2005·Journal of Cardiothoracic and Vascular Anesthesia·Monique L OgletreeChristine S Moravec
May 7, 2008·Laboratory Investigation; a Journal of Technical Methods and Pathology·Ichiro MoriyamaYoshikazu Kinoshita
Jul 31, 2013·Heart Failure Reviews·Chuichi Kawai, Akira Matsumori
Nov 2, 2019·The Journal of Physiology·Hugo S DíazRodrigo Del Rio
Mar 1, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Xi WangNaranjan S Dhalla
Nov 24, 2017·American Journal of Physiology. Heart and Circulatory Physiology·David C AndradeRodrigo Del Rio

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