Altered electromechanical coupling in the renal microvasculature during the early stage of diabetes mellitus

Clinical and Experimental Pharmacology & Physiology
P K Carmines, Keiji Fujiwara

Abstract

1. The early stage of type 1 diabetes mellitus (DM) is characterized by renal hyperfiltration, which promotes the eventual development of diabetic nephropathy. The hyperfiltration state is associated with afferent arteriolar dilation and diminished responsiveness of this vascular segment to a variety of vasoconstrictor stimuli, whereas efferent arteriolar diameter and vasoconstrictor responsiveness are typically unaltered. 2. The contractile status of preglomerular vascular smooth muscle appears to be tightly coupled to membrane potential (E(m)) and its influence on Ca(2+) influx through voltage-gated channels. Efferent arteriolar tone is largely independent of electromechanical events. Hence, defective electromechanical mechanisms in vascular smooth muscle should engender selective changes in preglomerular microvascular function, such as those evident during the early stage of DM. 3. Afferent arteriolar contractile responses to K(+)-induced depolarization and BAYK8644 are diminished 2 weeks after onset of DM in the rat. Similarly, depolarization-induced Ca(2+) influx and the resulting increase in intracellular [Ca(2+)] are abated in the preglomerular microvasculature of diabetic rats. The intracellular [Ca(2+)] response to dep...Continue Reading

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Citations

Oct 16, 2015·Experimental Biology and Medicine·Sarika Chaudhari, Rong Ma
Apr 4, 2017·Acta Physiologica·M SalomonssonC M Sorensen
Feb 22, 2018·Naunyn-Schmiedeberg's Archives of Pharmacology·José M CentenoFrancisco J Miranda
Aug 8, 2006·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Jian Hong ZhangCaryl E Hill
Jul 30, 2005·The Journal of Pharmacology and Experimental Therapeutics·Hao XueHai Wang
Dec 16, 2011·American Journal of Physiology. Renal Physiology·Charlotte Mehlin SorensenMax Salomonsson
Jun 21, 2017·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Aderemi Olaoluwa AlaladeFunlayo Odejinmi
Dec 6, 2003·American Journal of Physiology. Renal Physiology·Scott C ThomsonRoland C Blantz
Apr 3, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Catherine LauWilliam A Cupples

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