PMID: 9174896May 1, 1997Paper

Altered endothelial/pericyte ratio in Goto-Kakizaki rat retina

Journal of Diabetes and Its Complications
C D AgardhC G Ostenson

Abstract

The Goto-Kakizaki (GK) rat represents a model of hereditary non-insulin-dependent diabetes mellitus (NIDDM), characterized by nonobesity, mild hyperglycemia from early life, impaired glucose tolerance test results, and a markedly defective insulin response to glucose. The rats develop signs of both nephropathy and neuropathy, but, to our knowledge, retinal changes have not been reported so far in this model of NIDDM. Hence, the aim of the present study was to assess whether morphological vascular changes could be demonstrated in retinal vessel preparations of GK rats. The endothelial/pericyte ratio was found to be higher in GK rats aged 8 months as well as after 24-30 months compared to their matched controls (2.3 +/- 0.2 versus 2.0 +/- 0.1; p < 0.01, and 2.6 +/- 0.2 versus 1.9 +/- 0.1; p < 0.001, respectively). Furthermore, in 24 to 30-months-old GK rats, the endothelial/pericyte ratio was higher than in 8 month old GK rats (p < 0.05). Thus, the GK rat appears to be a suitable model for experimental studies of chronic complications, including diabetic retinopathy, in NIDDM.

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Citations

Sep 13, 2003·European Journal of Pharmacology·Takeshi OhtaFumihiko Yonemori
May 14, 1999·British Journal of Pharmacology·T OhtaK Wakitani
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Mar 4, 2014·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Roberto J FajardoMary L Bouxsein
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Apr 12, 2014·The American Journal of Psychology·Tyler BroderickAnastacia Sena-Jaramillo
Dec 7, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hiroshi Kitamura
Oct 8, 2018·Journal of Molecular Neuroscience : MN·Harshini Chakravarthy, Vasudharani Devanathan
Aug 25, 2017·Current Diabetes Reports·Ana Maria OlivaresNeena Haider

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